S J van Deventer

Leiden University Medical Center — Netherlands

Immunology and Microbiology · Life Sciences

45h-index10.5kcitations92works0.02yr avg
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Research Topics

Immune Response and Inflammation(22), Inflammatory Bowel Disease(20), Microscopic Colitis(9), Virus-based gene therapy research(8), S100 Proteins and Annexins(8)

Publications92 total

PhP.B Enhanced Adeno-Associated Virus Mediated-Expression Following Systemic Delivery or Direct Brain Administration
Frontiers in Bioengineering and Biotechnology·2021· 15 citedOpen Access
Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system
Brain Communications·2021· 6 citedOpen Access
Obituary J. W. ten Cate
Journal of Thrombosis and Haemostasis·2021Open Access
Transduction patterns in the CNS following various routes of AAV-5-mediated gene delivery
Gene Therapy·2020· 33 citedOpen Access
Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain
Molecular Therapy — Methods & Clinical Development·2020· 48 citedOpen Access
Development of an AAV5-based gene therapy for Fabry disease
Molecular Genetics and Metabolism·2020
Seroprevalence of Pre-Existing Nabs Against AAV1, 2, 5, 6 and 8 in South African Hemophilia B Patient Population
Blood·2019· 6 cited
Evaluation of a Blood Coagulation Factor IX Variant That Functions Independently of Factor VIII As an Alternative Treatment for Hemophilia A
Blood·2019
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease
Nucleic Acids Research·2019· 73 citedOpen Access
AAV5-miHTT Lowers Huntingtin mRNA and Protein without Off-Target Effects in Patient-Derived Neuronal Cultures and Astrocytes
Molecular Therapy — Methods & Clinical Development·2019· 69 citedOpen Access
Enhanced Factor IX Activity following Administration of AAV5-R338L “Padua” Factor IX versus AAV5 WT Human Factor IX in NHPs
Molecular Therapy — Methods & Clinical Development·2019· 33 citedOpen Access
Immunoadsorption enables successful rAAV5-mediated repeated hepatic gene delivery in nonhuman primates
Blood Advances·2019· 55 citedOpen Access
Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs
Molecular Therapy — Methods & Clinical Development·2019· 120 citedOpen Access
AAV5-miHTT Gene Therapy Demonstrates Sustained Huntingtin Lowering and Functional Improvement in Huntington Disease Mouse Models
Molecular Therapy — Methods & Clinical Development·2019· 85 citedOpen Access
Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy
Molecular Therapy — Nucleic Acids·2019· 91 citedOpen Access
Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients
Molecular Therapy — Nucleic Acids·2019· 58 citedOpen Access
I04 AAV5-MIHTT gene therapy demonstrates broad distribution and strong human mutant huntingtin lowering in a huntington disease minipig model
2018
AAV5-miHTT Gene Therapy Demonstrates Broad Distribution and Strong Human Mutant Huntingtin Lowering in a Huntington’s Disease Minipig Model
Molecular Therapy·2018· 157 citedOpen Access
AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease
Gene Therapy·2017· 100 citedOpen Access
Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington's Disease
Molecular Therapy — Nucleic Acids·2016· 131 citedOpen Access
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Frequent Co-authors

Tom van der Poll(12), Harald Petry(11), Pavlina Konstantinova(11), J W ten Cate(9), Melvin M. Evers(8), Hugo Ten Cate(6), J. Jansen(6), Cynthia Brouwers(6), Raygene Martier(6), Jana Miniarikova(5), Jaap Stoker(4), Marcel Levi(4), Jacek Lubelski(4), Daniël W. Hommes(4), Valérie Ferreira(4), Johannes B. Reitsma(3), Dasja Pajkrt(3), Jasper Florie(3), Astrid Vallès(3), Martin de Haan(3)