Rajeshwari D. Koilkonda

Oldham Council — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.1kcitations36works0.02yr avg
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Research Topics

Retinal Development and Disorders(21), Mitochondrial Function and Pathology(15), Virus-based gene therapy research(11), Photosynthetic Processes and Mechanisms(6), interferon and immune responses(4)

Publications36 total

Comparative Evaluation of Adeno-Associated Virus and Lentivirus Mediated Gene Transfer in Adult Rat Optic Nerve
SSRN Electronic Journal·2025Open Access
Potency study of high-titer AAV2 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in a preclinical mouse model.
Investigative Ophthalmology & Visual Science·2021Open Access
Targeted Krüppel-Like Factor 4 Gene Knock-Out in Retinal Ganglion Cells Improves Visual Function in Multiple Sclerosis Mouse Model
eNeuro·2020· 4 citedOpen Access
Gene Therapy with Single-Subunit Yeast NADH-Ubiquinone Oxidoreductase (NDI1) Improves the Visual Function in Experimental Autoimmune Encephalomyelitis (EAE) Mice Model of Multiple Sclerosis (MS)
Molecular Neurobiology·2020· 19 cited
Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)
Investigative Ophthalmology & Visual Science·2019· 2 citedOpen Access
Kruppel-like factor (KLF4) knockout in retinal ganglion cells improves visual function in Experimental Autoimmune Encephalomyelitis (EAE) mice model of optic neuritis
Investigative Ophthalmology & Visual Science·2019Open Access
Comparision of Allotopic and Mito targeted ND4 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in mice
Investigative Ophthalmology & Visual Science·2018Open Access
Low- and Medium-Dose Gene Therapy in Patients with Prior Unilateral LHON Does Not Prevent Further Visual Loss in the Treated Eye (S16.006)
Neurology·2018
Reply
Ophthalmology·2018
Gene Therapy for LHON Suppresses Neurodegeneration
Investigative Ophthalmology & Visual Science·2017· 1 citedOpen Access
Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in LHON Gene Therapy Clinical Trial Patients: An Update
Investigative Ophthalmology & Visual Science·2017Open Access
Gene Therapy for Leber Hereditary Optic Neuropathy
Ophthalmology·2017· 200 citedOpen Access
Gene Therapy for LHON : Low and Medium Dose Results (S26.004)
Neurology·2017· 1 cited
Reply
Ophthalmology·2017
LHON Gene Therapy Clinical Trial: Year 2 Results
Investigative Ophthalmology & Visual Science·2016Open Access
Assessment of Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in Serum and Ocular Fluid Samples of Leber’ Hereditary Optic Neuropathy (LHON) Gene Therapy Clinical Trial Patients
Investigative Ophthalmology & Visual Science·2016Open Access
Gene Therapy for Leber Hereditary Optic Neuropathy
Ophthalmology·2015· 226 cited
Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice
Proceedings of the National Academy of Sciences·2015· 42 citedOpen Access
Leber Hereditary Optic Neuropathy Gene Therapy (LHON) Clinical Trial: Initial Results
Investigative Ophthalmology & Visual Science·2015
608. Evaluation of Pre-Existing Neutralizing Antibodies Against Tyrosine-Mutant AAV2 in Leber Hereditary Optic Neuropathy (LHON) Patients
Molecular Therapy·2015· 1 citedOpen Access
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Frequent Co-authors

John Guy(26), Vittorio Porciatti(24), William J. Feuer(16), William W. Hauswirth(16), Byron L. Lam(13), Janet L. Davis(12), Phillip Gonzalez(10), Sanford L. Boye(10), Hong Yu(8), Venu Talla(8), Vince A. Chiodo(7), Alfred S. Lewin(6), Huijun Yuan(5), Tsung-Han Chou(5), Josephine M. Guy(5), Joyce Schiffman(3), Huijan Yuan(3), Anil K. Lalwani(2), Sacide S. Ozdemir(2), Marco Ruggeri(2)