Joseph G. Bruno

United States Military Academy — United States

Neuroscience · Life Sciences

18h-index1.2kcitations30works0.02yr avg
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Research Topics

Sleep and Wakefulness Research(11), Sleep and related disorders(9), Migraine and Headache Studies(7), Neuropeptides and Animal Physiology(7), Circadian rhythm and melatonin(6)

Publications30 total

Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2024
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2017· 8 citedOpen Access
Discovery of highly potent and selective orexin 1 receptor antagonists (1-SORAs) suitable for in vivo interrogation of orexin 1 receptor pharmacology
Bioorganic & Medicinal Chemistry Letters·2016· 18 citedOpen Access
Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine
Bioorganic & Medicinal Chemistry Letters·2015· 25 cited
Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties
Bioorganic & Medicinal Chemistry Letters·2015· 20 citedOpen Access
Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant
Bioorganic & Medicinal Chemistry Letters·2014· 22 citedOpen Access
Discovery of MK-3697: A selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia
Bioorganic & Medicinal Chemistry Letters·2014· 28 citedOpen Access
Synthesis and evaluation of carbon-linked analogs of dual orexin receptor antagonist filorexant
Bioorganic & Medicinal Chemistry Letters·2014· 9 citedOpen Access
Cover Picture: Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia (ChemMedChem 2/2014)
ChemMedChem·2014Open Access
Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia
ChemMedChem·2013· 65 cited
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
[ <sup>11</sup> C]MK-4232: The First Positron Emission Tomography Tracer for the Calcitonin Gene-Related Peptide Receptor
ACS Medicinal Chemistry Letters·2013· 25 citedOpen Access
MK-8825: A potent and selective CGRP receptor antagonist with good oral activity in rats
Bioorganic & Medicinal Chemistry Letters·2012· 27 citedOpen Access
Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Journal of Medicinal Chemistry·2011· 40 citedOpen Access
Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
Journal of Medicinal Chemistry·2010· 367 citedOpen Access
Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility
Bioorganic & Medicinal Chemistry Letters·2009· 14 citedOpen Access
Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an <i>N</i>,<i>N</i>‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
ChemMedChem·2009· 71 cited
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Frequent Co-authors

Christopher J. Winrow(11), John J. Renger(11), Paul J. Coleman(11), Tamara D. Cabalu(10), C. Meacham Harrell(9), Susan L. Garson(9), Anthony L. Gotter(8), Craig A. Stump(8), Wei Lemaire(7), Thomayant Prueksaritanont(7), Pamela L. Tannenbaum(7), Eric L. Moore(7), Scott D. Mosser(7), Christopher Salvatore(7), Christopher D. Cox(6), Anthony J. Roecker(6), Rodney A. Bednar(6), Donghui Cui(6), George D. Hartman(6), Joanne Stevens(6)