Rodney A. Bednar

United States Military Academy — United States

Medicine · Health Sciences

27h-index2.2kcitations65works0.02yr avg
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Research Topics

Platelet Disorders and Treatments(17), Neuroscience and Neuropharmacology Research(9), Antiplatelet Therapy and Cardiovascular Diseases(8), Migraine and Headache Studies(7), Heparin-Induced Thrombocytopenia and Thrombosis(7)

Publications64 total

Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective<i>N</i>‐methyl‐D‐aspartate receptor antagonist
Pharmacology Research & Perspectives·2015· 41 citedOpen Access
Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs)
Bioorganic & Medicinal Chemistry Letters·2013· 24 citedOpen Access
Cover Picture: Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties (ChemMedChem 3/2012)
ChemMedChem·2012· 4 cited
Discovery of [(2<i>R</i>,5<i>R</i>)‐5‐{[(5‐Fluoropyridin‐2‐yl)oxy]methyl}‐2‐methylpiperidin‐1‐yl][5‐methyl‐2‐(pyrimidin‐2‐yl)phenyl]methanone (MK‐6096): A Dual Orexin Receptor Antagonist with Potent Sleep‐Promoting Properties
ChemMedChem·2012· 121 cited
CCDC 857980: Experimental Crystal Structure Determination
The Cambridge Structural Database·2012Open Access
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents
Neuropharmacology·2011· 139 cited
Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists
ACS Chemical Neuroscience·2011· 24 cited
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia
Journal of Medicinal Chemistry·2010· 367 citedOpen Access
Identification of potent, highly constrained CGRP receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 14 citedOpen Access
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility
Bioorganic & Medicinal Chemistry Letters·2009· 14 citedOpen Access
Synthesis and evaluation of novel tricyclic benzo[4.5]cyclohepta[1.2]pyridine derivatives as NMDA/NR2B antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 7 citedOpen Access
Positive Allosteric Interaction of Structurally Diverse T-Type Calcium Channel Antagonists
Cell Biochemistry and Biophysics·2009· 74 cited
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2009· 8 citedOpen Access
Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an <i>N</i>,<i>N</i>‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats
ChemMedChem·2009· 71 cited
The discovery of highly potent CGRP receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 35 citedOpen Access
Potent benzimidazolone-based CGRP receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 13 citedOpen Access
Proline bis-amides as potent dual orexin receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2008· 71 citedOpen Access
α-Hydroxy amides as a novel class of bradykinin B1 selective antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 27 citedOpen Access
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2007· 27 citedOpen Access
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Frequent Co-authors

Bohumil Bednář(16), Scott D. Mosser(15), George D. Hartman(14), Stanley L. Gaul(14), Kenneth S. Koblan(9), Robert J. Gould(9), Joseph J. Lynch(8), John F. Fay(8), Wei Lemaire(7), Thomayant Prueksaritanont(7), Jacquelynn J. Cook(7), Marie A. Holahan(7), John A. McCauley(7), Christopher Salvatore(7), Stefanie A. Kane(7), Joseph P. Vacca(7), Joseph G. Bruno(6), Duane R. Reiss(6), John J. Renger(6), Michael E. Cunningham(6)