Taosheng Chen

St. Jude Children's Research Hospital — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

49h-index7.6kcitations295works3.62yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(67), Hormonal Regulation and Hypertension(41), Estrogen and related hormone effects(39), Drug Transport and Resistance Mechanisms(33), Protein Degradation and Inhibitors(32)

Publications295 total

An open-source screening platform accelerates discovery of drug combinations
Nature Communications·2025Open Access
Direct targeting and regulation of RNA polymerase II by cell signaling kinases
Science·2025
PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors
Nature Communications·2025Open Access
Subtle changes in ligand-receptor interactions dramatically alter transcriptional outcomes of pregnane X receptor modulators
Structure·2025Open Access
rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry Data
Analytical Chemistry·2025· 1 citedOpen Access
HTS Identifies NUP98-KDM5A-PHD3 Domain Ligands with Novel Scaffolds
ACS Medicinal Chemistry Letters·2025
Abstract 2451 Development of Small Molecules Targeting an Epigenetic Modulator for Pediatric Neuroblastoma
Journal of Biological Chemistry·2025Open Access
Decoding the selective chemical modulation of CYP3A4
Nature Communications·2025· 5 citedOpen Access
459 Development of small molecules targeting an epigenetic modulator for pediatric neuroblastoma
Journal of Clinical and Translational Science·2025Open Access
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Nature Communications·2025· 3 citedOpen Access
Addition/Correction to “First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy”
Journal of Medicinal Chemistry·2024Open Access
Development of BODIPY FL SNS 032 as a Versatile Probe for Constitutive Androstane Receptor and Multiple Kinases
ACS Medicinal Chemistry Letters·2024· 1 citedOpen Access
First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy
Journal of Medicinal Chemistry·2024· 7 citedOpen Access
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2
Nature Communications·2024· 18 citedOpen Access
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network
Structure·2024· 9 citedOpen Access
Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance
Cancer Research·2024
Abstract B005: BMP signaling determines neuroblastoma sensitivity to retinoic acid by directing cell fate
Cancer Research·2024
A new mode of inhibition
eLife·2024· 1 citedOpen Access
Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice
Clinical and Translational Medicine·2024· 2 citedOpen Access
Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon cytochrome P450 3A5-targeted inhibition
iScience·2024· 7 citedOpen Access
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Frequent Co-authors

Wenwei Lin(10), Sergio C. Chai(8), Yueming Wang(6), Su Sien Ong(6), Jonathan Low(6), Douglas R. Green(4), Burgess B. Freeman(4), Sharyn D. Baker(4), Laura J. Janke(4), Junmin Peng(4), Jaeki Min(4), Alex Sparreboom(4), William C. Wright(4), Lihua Wang(3), William L. Farrar(3), Tudor Moldoveanu(3), Lie Li(3), Alice A. Gibson(3), Shuiying Hu(3), Guoqing Du(3)