Peter K. LeMotte

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.9kcitations41works0.02yr avg
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Research Topics

Estrogen and related hormone effects(12), Retinoids in leukemia and cellular processes(11), Bacterial Genetics and Biotechnology(3), Protein Kinase Regulation and GTPase Signaling(3), Computational Drug Discovery Methods(3)

Publications41 total

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies
Oncogene·2016· 86 citedOpen Access
Notch2 Is Required for Inflammatory Cytokine-Driven Goblet Cell Metaplasia in the Lung
Cell Reports·2014· 253 citedOpen Access
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R‐spondin
EMBO Reports·2013· 107 citedOpen Access
TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types
Cancer Cell·2012· 160 citedOpen Access
Purification of the large ribosomal subunit via its association with the small subunit
Analytical Biochemistry·2009· 6 cited
Structural basis for the catalytic mechanism of human phosphodiesterase 9
Proceedings of the National Academy of Sciences·2008· 70 citedOpen Access
The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene
Protein Science·2007· 58 citedOpen Access
CCDC 616232: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
CCDC 616230: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
CCDC 616231: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
Theoretical and Experimental Design of Atypical Kinase Inhibitors:  Application to p38 MAP Kinase
Journal of Medicinal Chemistry·2005· 79 citedOpen Access
Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function
Protein Expression and Purification·2005· 23 cited
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics
Bioorganic & Medicinal Chemistry Letters·2003· 93 citedOpen Access
CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC
2002
Kinetic analysis of estrogen receptor/ligand interactions
Proceedings of the National Academy of Sciences·2002· 225 citedOpen Access
A crystallizable form of RIIβ regulatory domain obtained by limited proteolysis
Acta Crystallographica Section D Biological Crystallography·2000· 2 cited
HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH AMP
2000· 1 cited
Activation of Human Liver Glycogen Phosphorylase by Alteration of the Secondary Structure and Packing of the Catalytic Core
Molecular Cell·2000· 95 citedOpen Access
Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins
Analytical Biochemistry·1999· 213 cited
RARα antagonist RO 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines
International Journal of Cancer·1998· 47 cited
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Frequent Co-authors

Dennis E. Danley(11), Jayvardhan Pandit(9), Christian Apfel(7), Samuel P. Simons(7), Eric S. Marr(6), Mahmoud N. Mansour(6), Thomas R. Hynes(6), Mark Ammirati(5), Kieran F. Geoghegan(4), Siegfried Keidel(4), Kim F. McClure(4), Ellen R. Laird(4), John T. Barberia(4), Weiling Cai(4), Thomas J. Carty(4), Santo R. Cortina(4), A.J. Dipesa(4), Kathleen M. Donahue(4), Mark A. Dombroski(4), Christopher A. Gabel(4)