Samuel P. Simons

Biochemistry, Genetics and Molecular Biology · Life Sciences

6h-index517citations11works0.02yr avg
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Research Topics

Estrogen and related hormone effects(3), Protein Kinase Regulation and GTPase Signaling(2), Computational Drug Discovery Methods(2), Microtubule and mitosis dynamics(2), Cholinesterase and Neurodegenerative Diseases(2)

Publications11 total

CCDC 990952: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1
MedChemComm·2014· 36 cited
Purification of the large ribosomal subunit via its association with the small subunit
Analytical Biochemistry·2009· 6 cited
Structural basis for the catalytic mechanism of human phosphodiesterase 9
Proceedings of the National Academy of Sciences·2008· 70 citedOpen Access
The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene
Protein Science·2007· 58 citedOpen Access
Phosphorylation of serine residues in histidine-tag sequences attached to recombinant protein kinases: A cause of heterogeneity in mass and complications in function
Protein Expression and Purification·2005· 23 cited
Tandem mass spectrometry of multiply phosphorylated forms of a ‘histidine‐tag’ derived from a recombinant protein kinase expressed in bacteria
Rapid Communications in Mass Spectrometry·2005· 5 cited
Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics
Bioorganic & Medicinal Chemistry Letters·2003· 93 citedOpen Access
CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC
2002
Kinetic analysis of estrogen receptor/ligand interactions
Proceedings of the National Academy of Sciences·2002· 225 citedOpen Access
Additions and Corrections - Carboxyl-Assisted Hydrolyses. Synthesis and Hydrolysis of Diphenyl cis-2-(3-Carboxy)norbornyl Phosphates.
Journal of the American Chemical Society·1975· 1 cited

Frequent Co-authors

Peter K. LeMotte(7), Jayvardhan Pandit(5), Kieran F. Geoghegan(4), Dennis E. Danley(4), Mark Ammirati(3), Mahmoud N. Mansour(3), Frank S. Menniti(3), F.F. Vajdos(3), Lise R. Hoth(2), Robert L. Dow(2), Ernest S. Paight(2), Richard F. Hank(2), Peter Cornelius(2), William Newsome(2), Andrew G. Swick(2), Josephine Spitzer(2), Boris A. Chrunyk(2), Michele H. Rosner(2), Gayle K. Schulte(2), Bonnie F. Tate(2)