William Newsome

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index930citations9works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(3), Thyroid Disorders and Treatments(2), Mitochondrial Function and Pathology(2), Estrogen and related hormone effects(2), Pancreatic function and diabetes(2)

Publications9 total

Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TRβ subtype-selective thyromimetics
Bioorganic & Medicinal Chemistry Letters·2003· 93 citedOpen Access
CRYSTAL STRUCTURE OF HUMAN TR BETA LIGAND-BINDING DOMAIN COMPLEXED WITH A POTENT SUBTYPE-SELECTIVE THYROMIMETIC
2002
Isolation and characterization of the promoter region of the rat kidney-type glutaminase gene
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression·2001· 17 cited
Effects of l-Triiodothyronine and the Thyromimetic L-94901 on Serum Lipoprotein Levels and Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase, and Apo A-I Gene Expression
Biochemical Pharmacology·1998· 99 cited
Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.
Journal of Clinical Investigation·1996· 567 citedOpen Access
Anisoosmotic Regulation of Hepatic Gene Expression
Biological Chemistry Hoppe-Seyler·1996· 34 citedOpen Access
Modulation of phosphoenolpyruvate carboxykinase mRNA levels by the hepatocellular hydration state
Biochemical Journal·1994· 50 citedOpen Access
Control of liver cell function by the hydration state
Biochemical Society Transactions·1994· 23 cited
Increase of c‐<i>jun</i> mRNA upon hypo‐osmotic cell swelling of rat hepatoma cells
FEBS Letters·1994· 47 citedOpen Access

Frequent Co-authors

Peter Cornelius(3), Birgitta Noé(3), Barbara J. Stoll(3), Dieter Häussinger(3), Robert L. Dow(2), Ernest S. Paight(2), Richard F. Hank(2), Andrew G. Swick(2), Josephine Spitzer(2), Jayvardhan Pandit(2), Boris A. Chrunyk(2), Peter K. LeMotte(2), Dennis E. Danley(2), Michele H. Rosner(2), Mark Ammirati(2), Samuel P. Simons(2), Gayle K. Schulte(2), Bonnie F. Tate(2), Paul DaSilva‐Jardine(2), Ulrich Warskulat(2)