Sylvain Lengacher

Tamedia (Switzerland) — Switzerland

Neuroscience · Life Sciences

22h-index4.0kcitations41works2.52yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(11), Neuroinflammation and Neurodegeneration Mechanisms(9), Adipose Tissue and Metabolism(9), Mitochondrial Function and Pathology(8), Nerve injury and regeneration(5)

Publications41 total

GLUT1-DS Brain Organoids Exhibit Increased Sensitivity to Metabolic and Pharmacological Induction of Epileptiform Activity
Pharmaceuticals·2026Open Access
Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome
Frontiers in Neuroscience·2024· 5 citedOpen Access
Altered astrocytic and microglial homeostasis characterizes a decreased proinflammatory state in bipolar disorder
2023· 2 citedOpen Access
Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives
Frontiers in Physiology·2022· 272 citedOpen Access
Ganglioside GM1 Targets Astrocytes to Stimulate Cerebral Energy Metabolism
Frontiers in Pharmacology·2021· 28 citedOpen Access
Hyperpolarized <sup>13</sup>C Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood–Brain Barrier in the Cerebral Uptake and Metabolism of <scp>l</scp>-Lactate <i>in Vivo</i>
ACS Chemical Neuroscience·2018· 42 citedOpen Access
Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes
ACS Chemical Neuroscience·2018· 13 citedOpen Access
Impact of MCT1 Haploinsufficiency on the Mouse Retina
Advances in experimental medicine and biology·2018· 5 citedOpen Access
Role of MCT1 and CAII in skeletal muscle pH homeostasis, energetics, and function: <i>in vivo</i> insights from MCT1 haploinsufficient mice
The FASEB Journal·2017· 23 citedOpen Access
Astrocytic β <sub>2</sub> -adrenergic receptors mediate hippocampal long-term memory consolidation
Proceedings of the National Academy of Sciences·2016· 198 citedOpen Access
In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons
Cell Metabolism·2015· 552 citedOpen Access
Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory
PLoS ONE·2015· 104 citedOpen Access
Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases
Current Pharmaceutical Design·2015· 101 citedOpen Access
Channel-Mediated Lactate Release by K<sup>+</sup>-Stimulated Astrocytes
Journal of Neuroscience·2015· 181 citedOpen Access
P251 Résistance au développement d’une obésité induite par une diète riche en graisses et à ses altérations métaboliques chez la souris MCT1 haplo-insuffisante
Diabetes & Metabolism·2015
Monocarboxylate Transporter 1 (Mct1) Is Critical For Schwann Cell Function In Regenerating Peripheral Nerves
Infoscience (Ecole Polytechnique Fédérale de Lausanne)·2015Open Access
Astrocytes may be behind the pathogenesis of 22q11
Infoscience (Ecole Polytechnique Fédérale de Lausanne)·2015Open Access
Cerebral glucose uptake measurements on a single cell level reveal higher transport in astrocytes in vivo
Infoscience (Ecole Polytechnique Fédérale de Lausanne)·2015Open Access
Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush
Experimental Neurology·2014· 90 citedOpen Access
Control of Mitochondrial pH by Uncoupling Protein 4 in Astrocytes Promotes Neuronal Survival
Journal of Biological Chemistry·2014· 29 citedOpen Access
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Frequent Co-authors

Pierre J. Magistretti(35), Luc Pellerin(17), Brett M. Morrison(7), Akivaga Tsingalia(7), Charles Finsterwald(5), Bernard L. Schneider(4), Patrick Aebischer(4), Jean‐Yves Chatton(4), Matthias T. Wyss(3), Marc Zuend(3), Igor Allaman(3), Lionel Carneiro(3), J. D. Rothstein(3), Youngjin Lee(2), Mohamed H. Farah(2), Lin Jin(2), Jeffrey D. Rothstein(2), Philipp Mächler(2), Jillian L. Stobart(2), Alejandro San Martín(2)