Siska Van Belle

KU Leuven — Belgium

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index290citations29works2.72yr avg
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Research Topics

Protein Degradation and Inhibitors(9), Genetics and Neurodevelopmental Disorders(8), Ubiquitin and proteasome pathways(7), HIV Research and Treatment(6), Acute Myeloid Leukemia Research(4)

Publications29 total

Absence of Ledgf in mouse brain affects the Kmt2a/b and polycomb balance, synaptic transmission and motor function
Acta Neuropathologica Communications·2026Open Access
289 Clinically approved β2 agonist formoterol enhances CFTR modulator rescue of N1303K-CFTR via a dual mode of action
Journal of Cystic Fibrosis·2025
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Nature Communications·2025· 10 citedOpen Access
Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer·2024· 4 citedOpen Access
LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates
Structure·2024· 4 citedOpen Access
A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia
Science Advances·2024· 6 citedOpen Access
HIV integrase compacts viral DNA into biphasic condensates
2024· 3 citedOpen Access
HIV integrase compacts viral DNA into biphasic condensates
2024Open Access
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family
European Journal of Medicinal Chemistry·2024· 5 citedOpen Access
3013 – LEDGF/P75 PLAYS OPPOSING ROLES IN CHEMORESISTANCE IN DIFFERENT LEUKEMIAS
Experimental Hematology·2024
LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
2024Open Access
HIV integrase compacts viral DNA into biphasic condensates
2024· 1 citedOpen Access
The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function
Cells·2024· 8 citedOpen Access
LEDGF Interacts with the NID of MeCP2 and Modulates MeCP2 Condensates
SSRN Electronic Journal·2024Open Access
Rational Fragment-Based Design of Compounds Targeting the Ledgf Pwwp Domain
SSRN Electronic Journal·2024Open Access
PB1704: LEDGF/P75 ASSOCIATED WITH CHEMORESISTANCE IN MIXED-LINEAGE LEUKEMIA
HemaSphere·2023Open Access
BET-Independent Murine Leukemia Virus Integration Is Retargeted <i>In Vivo</i> and Selects Distinct Genomic Elements for Lymphomagenesis
Microbiology Spectrum·2022· 6 citedOpen Access
Expansion microscopy allows high resolution single cell analysis of epigenetic readers
Nucleic Acids Research·2022· 16 citedOpen Access
Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment
Bioorganic & Medicinal Chemistry Letters·2022· 10 cited
BET-independent MLV integration is retargeted <i>in vivo</i> and selects distinct genomic elements for lymphomagenesis
2022Open Access
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Frequent Co-authors

Zeger Debyser(25), Frauke Christ(23), Sara El Ashkar(6), Jan De Rijck(6), Václav Veverka(6), Muluembet Akele(6), Tine Brouns(5), Steven Goossens(4), Pieter Van Vlierberghe(4), Alessandro Canella(4), Kateřina Čermáková(3), Anne Bruggemans(3), Filip Matthijssens(3), Vanda Lux(3), Saskia Lesire(3), Rodrigo Lata(3), Yannick Hoogvliets(3), Kune Herrebosch(3), Paulien Van de Velde(3), Anouk Speleers(3)