Zeger Debyser

Hermitage Museum — United States

Immunology and Microbiology · Life Sciences

74h-index18.4kcitations761works5.72yr avg
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Research Topics

HIV Research and Treatment(336), HIV/AIDS drug development and treatment(330), Virus-based gene therapy research(130), Biochemical and Molecular Research(97), RNA Interference and Gene Delivery(52)

Publications756 total

Deciphering the HIV reservoir: From epigenetic regulators to RNA-mediated regulation
Chinese Chemical Letters·2025
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Nature Communications·2025· 10 citedOpen Access
Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer·2024· 4 citedOpen Access
PP3.7 – 00002 Towards a functional cure for HIV-1 infection: BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription
Journal of Virus Eradication·2024Open Access
LEDGF interacts with the NID domain of MeCP2 and modulates MeCP2 condensates
Structure·2024· 4 citedOpen Access
A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia
Science Advances·2024· 6 citedOpen Access
HIV integrase compacts viral DNA into biphasic condensates
2024· 3 citedOpen Access
HIV integrase compacts viral DNA into biphasic condensates
2024Open Access
Rational fragment-based design of compounds targeting the PWWP domain of the HRP family
European Journal of Medicinal Chemistry·2024· 5 citedOpen Access
317 Improving N1303K rescue by combining elexacaftor/tezacaftor/ivacaftor with β2 agonist formoterol
Journal of Cystic Fibrosis·2024
3013 – LEDGF/P75 PLAYS OPPOSING ROLES IN CHEMORESISTANCE IN DIFFERENT LEUKEMIAS
Experimental Hematology·2024
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells
Cell Reports Medicine·2024· 48 citedOpen Access
LEDGF interacts with the NID of MeCP2 and modulates MeCP2 condensates
2024Open Access
EDITORIAL: Putting HIV in the big sleep with the block-and-lock strategy
Current Opinion in HIV and AIDS·2024· 1 citedOpen Access
HIV integrase compacts viral DNA into biphasic condensates
2024· 1 citedOpen Access
Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review
Reviews in Medical Virology·2024· 14 citedOpen Access
New latency-promoting agents for a block-and-lock functional cure strategy
Current Opinion in HIV and AIDS·2024· 9 citedOpen Access
The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function
Cells·2024· 8 citedOpen Access
LEDGF Interacts with the NID of MeCP2 and Modulates MeCP2 Condensates
SSRN Electronic Journal·2024Open Access
Rational Fragment-Based Design of Compounds Targeting the Ledgf Pwwp Domain
SSRN Electronic Journal·2024Open Access
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Frequent Co-authors

Frauke Christ(18), Rik Gijsbers(15), Veerle Baekelandt(11), Myriam Witvrouw(11), Erik De Clercq(10), Jan De Rijck(10), Yves Engelborghs(6), Katrien Busschots(6), Chris Van den Haute(6), Dominique Schols(5), Linos Vandekerckhove(5), Jonas Demeulemeester(5), Sofie Vets(5), Peter Cherepanov(4), Jaan Toelen(4), Rudi Pauwels(4), Stéphane Emiliani(4), Bénédicte Van Maele(4), Christophe Pannecouque(4), Bart Nuttin(4)