János Éles

Gedeon Richter (Hungary) — Hungary

Engineering · Physical Sciences

12h-index462citations46works1.62yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(17), Receptor Mechanisms and Signaling(8), Analytical Chemistry and Chromatography(5), Nicotinic Acetylcholine Receptors Study(5), Nanomaterials for catalytic reactions(5)

Publications46 total

The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger
Journal of Medicinal Chemistry·2026Open Access
Correction to “Discovery of an In Vitro and In Vivo Potent Nicotinic α7 Positive Allosteric Modulator Clinical Candidate Molecule (RGH-857)”
Journal of Medicinal Chemistry·2026
Discovery of an In Vitro and In Vivo Potent Nicotinic α7 Positive Allosteric Modulator Clinical Candidate Molecule (RGH-857)
Journal of Medicinal Chemistry·2025
Continuous-flow synthesis of 1,4,6,7-tetrahydro-5<i>H</i>-[1,2,3]triazolo[4,5-<i>c</i>]pyridines towards key intermediates of clinical candidates JNJ-54175446 and zanvipixant (JNJ-55308942) with antidepressant activity
RSC Advances·2025· 2 citedOpen Access
Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds
Bioorganic & Medicinal Chemistry Letters·2024
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1<i>H</i>-Tetrazoles
Organic Process Research & Development·2024· 3 cited
Transaminase-catalysis to produce trans-4-substituted cyclohexane-1-amines including a key intermediate towards cariprazine
Communications Chemistry·2024· 4 citedOpen Access
Novel-Type GABA<sub>B</sub> PAMs: Structure–Activity Relationship in Light of the Protein Structure
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Discovery of Novel Steroid-Based Histamine H<sub>3</sub> Receptor Antagonists/Inverse Agonists
Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Design, synthesis and biological evaluation of novel cyclic malonamide derivatives as selective RIPK1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2024· 1 cited
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Journal of Medicinal Chemistry·2023· 2 citedOpen Access
Safe and Rapid Synthesis and Utilization of 2-Azidopyridine and Related Derivatives<i>via</i> Continuous Flow Diazotization
Current Organic Chemistry·2023· 2 cited
6-Aryl-quinazolines as novel GABAB receptor positive allosteric modulators
Bioorganic & Medicinal Chemistry Letters·2022· 2 citedOpen Access
hERG Optimization of Benzofuro−Pyridine and Pyrazino−Indole Derivatives as MCHR1 Antagonists
ChemMedChem·2022· 6 cited
CNS kutatás egy nemzetközi cégnél – az elmúlt 15 év gyógyszerkémiai tapasztalatai
Magyar kémiai folyóirat, Kémiai közlemények·2022Open Access
Multistep batch-flow hybrid synthesis of a terbinafine precursor
Journal of Flow Chemistry·2021· 1 citedOpen Access
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor
European Journal of Medicinal Chemistry·2021· 2 citedOpen Access
C-N Bond Formation by Consecutive Continuous-Flow Reductions towards A Medicinally Relevant Piperazine Derivative
Molecules·2021· 2 citedOpen Access
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
European Journal of Medicinal Chemistry·2021· 15 citedOpen Access
Evolution of flow-oriented design strategies in the continuous preparation of pharmaceuticals
Reaction Chemistry & Engineering·2020· 38 cited
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Frequent Co-authors

István Greiner(32), Péter Bana(11), Ferenc Faigl(8), János Kóti(8), István Ledneczki(8), György Lévay(8), Zsolt Némethy(8), Pál Tapolcsányi(7), Balázs Krámos(7), Ottilia Balázs(7), Róbert Örkényi(6), Sándor Kolok(6), Mónika Vastag(6), M. KAJTAR‐PEREDY(6), Lajos Szabó(6), Márta Thán(6), Zoltán Szakács(5), Gábor Hornyánszky(5), Áron Szigetvári(5), Gyula Beke(5)