Zsolt Némethy

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index788citations30works1.22yr avg
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Research Topics

Receptor Mechanisms and Signaling(22), Neuroscience and Neuropharmacology Research(8), Nicotinic Acetylcholine Receptors Study(8), Neurotransmitter Receptor Influence on Behavior(6), Mast cells and histamine(4)

Publications30 total

Correction to “Discovery of an In Vitro and In Vivo Potent Nicotinic α7 Positive Allosteric Modulator Clinical Candidate Molecule (RGH-857)”
Journal of Medicinal Chemistry·2026
Discovery of an In Vitro and In Vivo Potent Nicotinic α7 Positive Allosteric Modulator Clinical Candidate Molecule (RGH-857)
Journal of Medicinal Chemistry·2025
Analysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients
iScience·2025Open Access
Discovery of Novel Steroid-Based Histamine H<sub>3</sub> Receptor Antagonists/Inverse Agonists
Journal of Medicinal Chemistry·2024· 3 citedOpen Access
Cellular Mechanisms of Cognitive Enhancement: The <i>In Vivo</i> Modulation of the Firing Activity and the Responsiveness of Rat Hippocampal Neurons by Memantine and Alpha7 Nicotinic Acetylcholine Receptor Ligands
ASN NEURO·2024· 3 citedOpen Access
Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560)
Journal of Medicinal Chemistry·2023· 2 citedOpen Access
Combination of memantine and alpha7 nicotinic acetylcholine receptor ligands exerts superior efficacy over monotreatments to improve cognitive performance of aged rats
2023Open Access
Convergent cross-species pro-cognitive effects of RGH-235, a new potent and selective histamine H3 receptor antagonist/inverse agonist
European Journal of Pharmacology·2021· 2 citedOpen Access
Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter‐mediated nonquantal dopamine release
Physiological Reports·2021· 7 citedOpen Access
HTS-based discovery and optimization of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor
European Journal of Medicinal Chemistry·2021· 2 citedOpen Access
Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach
European Journal of Medicinal Chemistry·2021· 15 citedOpen Access
&lt;p&gt;Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine&lt;/p&gt;
Drug Design Development and Therapy·2019· 48 citedOpen Access
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists. Part 2. Versatile steroidal carboxamide derivatives
Bioorganic & Medicinal Chemistry Letters·2019· 3 citedOpen Access
Discovery of novel steroidal histamine H3 receptor antagonists/inverse agonists
Bioorganic & Medicinal Chemistry Letters·2017· 7 citedOpen Access
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands
Bioorganic & Medicinal Chemistry Letters·2016· 4 citedOpen Access
The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands
Bioorganic & Medicinal Chemistry Letters·2015· 2 citedOpen Access
Poster #S17 ARE DOPAMINE PARTIAL AGONIST ANTIPSYCHOTICS SIMILAR? PRECLINICAL COMPARISON OF ARIPIPRAZOLE, BIFEPRUNOX AND CARIPRAZINE
Schizophrenia Research·2014
α7 Nicotinic acetylcholine receptors and their role in cognition
Brain Research Bulletin·2012· 91 cited
THE PHARMACOLOGY OF CARIPRAZINE, A NOVEL D3-PREFERRING D3/D2 ANTAGONIST-PARTIAL AGONIST ANTIPSYCHOTIC
Schizophrenia Research·2010
Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile
Journal of Pharmacology and Experimental Therapeutics·2010· 359 cited
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Frequent Co-authors

Balázs Lendvai(11), István Ledneczki(11), Béla Kiss(10), György Lévay(10), Ottilia Balázs(8), János Éles(8), István Gyertyán(7), Pál Tapolcsányi(7), István Greiner(7), Sándor Kolok(7), Sándor Mahó(6), Viktor Román(6), Katalin Sághy(5), Eszter Gábor(5), Balázs Krámos(5), Márta Thán(5), Judit Laszy(5), Mónika Vastag(5), Eva Marina Schmidt(4), I. Laszlovszky(4)