Michael Zhuo Wang

Medicine · Health Sciences

22h-index4.5kcitations62works2.12yr avg
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Research Topics

Trypanosoma species research and implications(28), Research on Leishmaniasis Studies(25), Synthesis and Biological Evaluation(19), Pharmacogenetics and Drug Metabolism(12), Drug Transport and Resistance Mechanisms(9)

Publications61 total

A Parent–Metabolite Middle-Out PBPK Model for Genistein and Its Glucuronide Metabolite in Rats: Integrating Liver and Enteric Metabolism with Hepatobiliary and Enteroluminal Transport to Assess Glucuronide Recycling
Pharmaceutics·2025Open Access
Comparative transcriptomic profiling of drug-metabolizing enzymes and drug transporters in rabbit ocular subtissues, liver, and duodenum
Drug Metabolism and Disposition·2025· 2 citedOpen Access
Longitudinal curriculum design shows promise to improve pharmacogenomics education in an observational study
Currents in Pharmacy Teaching and Learning·2025· 1 cited
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles
Nature Communications·2024· 10 citedOpen Access
Molecular Characterization of Sterol C4-Methyl Oxidase in Leishmania major
International Journal of Molecular Sciences·2024· 1 citedOpen Access
N-substituted-4-(pyridin-4-ylalkyl)piperazine-1-carboxamides and related compounds as Leishmania CYP51 and CYP5122A1 inhibitors
Bioorganic & Medicinal Chemistry·2024· 3 citedOpen Access
Molecular Characterization of Sterol C4-Methyl Oxidase in Leishmania major
Preprints.org·2024Open Access
Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach
Antimicrobial Agents and Chemotherapy·2024· 1 citedOpen Access
Physiologically based pharmacokinetic model for miltefosine in mice
Drug Metabolism and Pharmacokinetics·2024
Pharmacogenomics education strategies in the United States pharmacy school curricula
Currents in Pharmacy Teaching and Learning·2024· 5 cited
CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles
2023· 2 citedOpen Access
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform
ACS Central Science·2022· 9 citedOpen Access
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates
Nature Microbiology·2022· 65 citedOpen Access
Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway
International Journal for Parasitology Drugs and Drug Resistance·2022· 27 citedOpen Access
Development of a UPLC-MRM-based targeted proteomic method to profile subcellular organelle marker proteins from human liver tissues
Scientific Reports·2022· 2 citedOpen Access
Synthesis and Antileishmanial Evaluation of Arylimidamide–Azole Hybrids Containing a Phenoxyalkyl Linker
ACS Infectious Diseases·2021· 9 citedOpen Access
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis
UNC Libraries·2020Open Access
CYP1A1 and CYP1B1-Mediated Biotransformation of the Antitrypanosomal Methamidoxime Prodrug DB844 Forms Novel Metabolites Through Intramolecular Rearrangement
UNC Libraries·2020Open Access
Evaluation of Arylimidamides DB1955 and DB1960 as Candidates against Visceral Leishmaniasis and Chagas' Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies
UNC Libraries·2020Open Access
Pharmacokinetic Comparison To Determine the Mechanisms Underlying the Differential Efficacies of Cationic Diamidines against First- and Second-Stage Human African Trypanosomiasis
UNC Libraries·2020· 2 citedOpen Access
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Frequent Co-authors

Sihyung Yang(18), Richard R. Tidwell(12), Karl A. Werbovetz(12), Reto Brun(11), David W. Boykin(9), Judy Qiju Wu(9), Tanja Wenzler(8), James Edwin Hall(7), Mei Feng(7), Mary F. Paine(6), Yiru Jin(6), David W. Boykin(5), Arlene S. Bridges(5), Xiaohua Zhu(5), Kai Zhang(5), Junan Li(5), W. David Wilson(4), Chad E. Stephens(4), Sally Kornbluth(4), Donald A. Patrick(4)