John G. Lock

UNSW Sydney — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.7kcitations70works0.82yr avg
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Research Topics

Cellular Mechanics and Interactions(20), Cancer Cells and Metastasis(15), Cell Image Analysis Techniques(15), Advanced Fluorescence Microscopy Techniques(11), Cellular transport and secretion(10)

Publications70 total

Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation
Molecular Biology of the Cell·2025Open Access
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy
Nature Neuroscience·2025· 3 citedOpen Access
Uncertainty-Aware Deep Learning for Multi-Metric and Dose-Specific Prediction of Drug Synergy
2025Open Access
Deep multiplexed 50-marker imaging of circulating tumor cells expands actionable biomarker profiling for precision oncology
2025Open Access
Data from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025· 1 citedOpen Access
Supplementary Table 1 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Figures S1-9 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Supplementary Table 2 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Generative semantic multiplexing (SemaPlex) for accessible and scalable multiplexed fluorescence imaging
2025Open Access
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
Nature Communications·2025· 1 citedOpen Access
Image quality metrics fail to accurately represent biological information in fluorescence microscopy
2025· 3 citedOpen Access
The effect of image acquisition settings and image processing on fluorescence microscopy data and downstream analysis
2025
Gene-Corrected Basal Cells Restore CFTR In Vitro; Transplants Regenerate Epithelium in a Preclinical Sinus Model
2025Open Access
Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation
2025Open Access
AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
Cancer Discovery·2025· 2 citedOpen Access
Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data
Nature Communications·2025· 4 citedOpen Access
A selective inhibitor of oncogenic JNK signalling perturbs metastatic outgrowth of triple-negative breast cancer through metabolic blockade
2025Open Access
Abstract A031: Harnessing the potential of circulating tumour cells for precision diagnostics via multiplexed imaging of the levels and subcellular localizations of over 50 cell identity, state and signaling markers per cell
Clinical Cancer Research·2024· 2 cited
Seeing more with less: Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data
2024Open Access
Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport
Research Square (Research Square)·2023· 1 citedOpen Access
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Frequent Co-authors

Staffan Strömblad(18), Xiaowei Gong(7), Jennifer L. Stow(6), Christine L. Chaffer(6), Beatriz P. San Juan(5), Smita Krishnaswamy(5), Daniel Neumann(5), Helene Olofsson(4), Paul A. Gleeson(4), Pablo Hernández-Varas(4), Hamdah Shafqat-Abbasi(4), Jacob M. Kowalewski(4), Felix V Kohane(4), Erik Meijering(4), Therese M. Becker(4), Shabarni Gupta(4), Matt Jones(3), Anna Oddone(3), Melike Lakadamyali(3), Martin J. Humphries(3)