Christine L. Chaffer

Garvan Institute of Medical Research — Australia

Medicine · Health Sciences

23h-index13.7kcitations83works2.32yr avg
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Research Topics

Cancer Cells and Metastasis(31), Bladder and Urothelial Cancer Treatments(14), Single-cell and spatial transcriptomics(12), Fibroblast Growth Factor Research(11), Cancer Genomics and Diagnostics(10)

Publications81 total

Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response
Nucleic Acids Research·2026Open Access
Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation
Molecular Biology of the Cell·2025Open Access
Data from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025· 1 citedOpen Access
Supplementary Table 1 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Figures S1-9 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Supplementary Table 2 from AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
2025Open Access
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
Nature Communications·2025· 1 citedOpen Access
Capillary constrictions prime cancer cell tumorigenicity through PIEZO1
2025Open Access
Isoform-specific single-cell perturb-seq reveals distinct functions of alternative promoters in drug response
2025
Epithelial–mesenchymal cell state heterogeneity predetermines differential phospho-signaling responses to EGF stimulation
2025Open Access
AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity
Cancer Discovery·2025· 2 citedOpen Access
Macrophages direct location-dependent recall of B cell memory to vaccination
Cell·2025· 15 citedOpen Access
Abstract 4744: State-gating cancer to prevent chemotherapy-resistance
Cancer Research·2025
EXTH-26. EXPLORING THE ROLE OF ANDROGEN RECEPTOR SIGNALING IN GLIOBLASTOMA IN AN ORTHOTOPIC ANIMAL MODEL
Neuro-Oncology·2024Open Access
Targeting androgen receptor signaling in glioblastoma: A novel biomarker and therapeutic approach.
Journal of Clinical Oncology·2024
4CAST: A phase 1b dose exploration, open-label, single-center study evaluating the safety of INO-464 in combination with chemotherapy in patients with metastatic breast cancer.
Journal of Clinical Oncology·2024· 1 cited
Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer
iScience·2024· 17 citedOpen Access
AAnet resolves a continuum of spatially-localized cell states to unveil tumor complexity
2024· 4 citedOpen Access
Chemotherapy and the Extra-Tumor Immune Microenvironment: EXTRA-TIME
Cancer Discovery·2024· 5 citedOpen Access
Revealing dynamic temporal regulatory networks driving cancer cell state plasticity with neural ODE-based optimal transport
Research Square (Research Square)·2023· 1 citedOpen Access
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Frequent Co-authors

Robert A. Weinberg(17), Beatriz P. San Juan(14), Smita Krishnaswamy(10), Erik W. Thompson(8), John G. Lock(8), Elizabeth D. Williams(7), Carley A. Purcell(7), Ferenc Reinhardt(6), Aarthi Venkat(6), David van Dijk(5), Nemanja D. Marjanovic(5), Matthew Amodio(5), Scott E. Youlten(5), Leonard D. Goldstein(5), Shabarni Gupta(5), Brian Bierie(4), Daniel B. Burkhardt(4), Diwakar R. Pattabiraman(3), Christina Scheel(3), George W. Bell(3)