Dieder Moechars

Janssen (Belgium) — Belgium

Medicine · Health Sciences

44h-index6.0kcitations89works13.02yr avg
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Research Topics

Alzheimer's disease research and treatments(34), Regulation of Appetite and Obesity(16), Neuroscience and Neuropharmacology Research(12), Nuclear Receptors and Signaling(12), Biochemical Analysis and Sensing Techniques(11)

Publications89 total

The Alzheimer’s disease–linked protease BACE2 cleaves VEGFR3 and modulates its signaling
Journal of Clinical Investigation·2024· 13 citedOpen Access
Neurophysiological effects of human-derived pathological tau conformers in the APPKM670/671NL.PS1/L166P amyloid mouse model of Alzheimer’s disease
Scientific Reports·2022· 7 citedOpen Access
Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice
Neurobiology of Disease·2021· 15 citedOpen Access
Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils
Frontiers in Aging Neuroscience·2021· 13 citedOpen Access
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
Journal of Biological Chemistry·2021· 40 citedOpen Access
Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads
ACS Medicinal Chemistry Letters·2019· 33 citedOpen Access
BACE2 distribution in major brain cell types and identification of novel substrates
Life Science Alliance·2018· 65 citedOpen Access
Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice
Experimental Neurology·2017· 14 citedOpen Access
BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer’s Disease Markers in Elderly Healthy Participants
Journal of Alzheimer s Disease·2017· 33 citedOpen Access
Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models
Scientific Reports·2017· 33 citedOpen Access
Discovery of <i>N</i>-(Pyridin-4-yl)-1,5-naphthyridin-2-amines as Potential Tau Pathology PET Tracers for Alzheimer’s Disease
Journal of Medicinal Chemistry·2017· 40 cited
IP3 accumulation and/or inositol depletion: two downstream lithium’s effects that may mediate its behavioral and cellular changes
Translational Psychiatry·2016· 48 citedOpen Access
Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ‐54861911, a potent oral BACE inhibitor
Alzheimer s & Dementia Translational Research & Clinical Interventions·2016· 59 citedOpen Access
1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads
Journal of Medicinal Chemistry·2015· 76 citedOpen Access
Tau Positron Emission Tomography (PET) Imaging: Past, Present, and Future
Journal of Medicinal Chemistry·2015· 106 cited
Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice
PLoS ONE·2013· 91 citedOpen Access
Inositol-Related Gene Knockouts Mimic Lithium’s Effect on Mitochondrial Function
Neuropsychopharmacology·2013· 47 citedOpen Access
P2–414: O‐GlcNAc‐ase inhibitor improves the clinical conditions of Alzheimer's disease mice
Alzheimer s & Dementia·2013
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
Molecular Psychiatry·2013· 419 citedOpen Access
Inactivation of the Constitutively Active Ghrelin Receptor Attenuates Limbic Seizure Activity in Rodents
Neurotherapeutics·2012· 34 citedOpen Access
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Frequent Co-authors

Fred Van Leuven(11), Ilse Dewachter(8), Bart De Strooper(8), Luc Ver Donck(7), Inge Depoortere(6), Marc Mercken(5), Kim Cryns(5), Cuno Kuipéri(5), Bernard Coulie(5), Frederik Rombouts(5), Harrie J. M. Gijsen(5), Kristin Lorent(4), Ina Tesseur(4), Kurt Spittaels(4), Chris Van den Haute(4), Ilse Goris(4), Thomas Steckler(4), Barbara Smet(4), T. L. Peeters(4), Gregor J. Macdonald(4)