Kurt Spittaels

Janssen (Belgium) — Belgium

Medicine · Health Sciences

22h-index3.5kcitations32works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(14), Neurobiology and Insect Physiology Research(5), Insect Resistance and Genetics(5), Insect Utilization and Effects(5), Wnt/β-catenin signaling in development and cancer(4)

Publications32 total

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients
Hepatology·2023· 44 citedOpen Access
Novel markers to predict virological and clinical relapse onset following antiviral treatment discontinuation in chronic hepatitis B patients
Journal of Hepatology·2020Open Access
The Orphan G Protein–Coupled Receptor 3 Modulates Amyloid-Beta Peptide Generation in Neurons
Science·2009· 193 cited
Peroxisome Proliferator-Activated Receptor γ Induces a Clearance Mechanism for the Amyloid-β Peptide
Journal of Neuroscience·2004· 168 citedOpen Access
Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway
The Journal of Cell Biology·2004· 170 citedOpen Access
A knock down screen for identification of putative Alzheimer's disease modifying drugable genes that modulate amyloid levels
UCL Discovery (University College London)·2004
P4-373 A knock down screen for identification of putative Alzheimer's disease modifying drugable genes that modulate amyloid levels
Neurobiology of Aging·2004
Presenilins Mutated at Asp-257 or Asp-385 Restore Pen-2 Expression and Nicastrin Glycosylation but Remain Catalytically Inactive in the Absence of Wild Type Presenilin
Journal of Biological Chemistry·2003· 110 citedOpen Access
Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice
Neuroscience·2002· 103 cited
Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice
Journal of Neuroscience·2002· 238 citedOpen Access
Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau
Neurobiology of Disease·2002· 29 citedOpen Access
Differential expression of brain proteins in glycogen synthase kinase-3 transgenic mice: A proteomics point of view
PROTEOMICS·2002· 58 cited
Differential expression of brain proteins in glycogen synthase kinase-3 transgenic mice: A proteomics point of view
PROTEOMICS·2002· 1 cited
Phosphorylation of Protein Tau and Rescue of Protein Tau‐induced Axonopathy by GSK‐3β in GSK‐3β×htau40 Double Transgenic Mice
2001
Modelling Alzheimer's disease in multiple transgenic mice
Biochemical Society Symposia·2001· 20 cited
Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice
Neurobiology of Disease·2001· 81 citedOpen Access
Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice
Journal of Biological Chemistry·2000· 317 citedOpen Access
Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons
American Journal Of Pathology·2000· 229 citedOpen Access
Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice
Experimental Gerontology·2000· 74 cited
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
Neurobiology of Aging·2000· 10 cited
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Frequent Co-authors

Chris Van den Haute(15), Fred Van Leuven(10), Jo Van Dorpe(9), Hugo Geerts(8), Arnold De Loof(8), Liliane Schoofs(8), Ilse Dewachter(6), Ina Tesseur(6), Marc Mercken(6), Bart De Strooper(6), Dieder Moechars(5), Pascal Merchiers(5), Koen Bruynseels(4), Kris Vandezande(4), Isabelle Laenen(4), Ruth J. F. Loos(4), Bart Devreese(4), Anne Vankeerberghen(4), Luc Grauwels(4), Raf Sciot(3)