Geoffrey G. Hesketh

Lunenfeld-Tanenbaum Research Institute — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index2.9kcitations59works1.52yr avg
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Research Topics

Cellular transport and secretion(21), Cardiac electrophysiology and arrhythmias(12), Biotin and Related Studies(8), Ion channel regulation and function(7), CRISPR and Genetic Engineering(7)

Publications59 total

Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase
iScience·2025· 1 citedOpen Access
Cargo-selective regulation of clathrin-mediated endocytosis by AMP-activated protein kinase
2024· 1 citedOpen Access
Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction
Science Advances·2024· 7 citedOpen Access
Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independent
2024Open Access
Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independent
2024Open Access
Control of GSK3β nuclear localization by amino acid signaling requires GATOR1 but is mTORC1-independent
2024Open Access
SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation
Journal of Biological Chemistry·2023· 17 citedOpen Access
Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction
2023· 1 citedOpen Access
SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolism
2022· 2 citedOpen Access
Integrative Structural Biology to Understand Biological Complexity
Molecular & Cellular Proteomics·2022Open Access
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7
Life Science Alliance·2022· 29 citedOpen Access
Endosomal LC3C-pathway selectively targets plasma membrane cargo for autophagic degradation
Nature Communications·2022· 28 citedOpen Access
Proximity‐dependent sensors for signaling
The FASEB Journal·2022
Author Correction: A proximity-dependent biotinylation map of a human cell
Nature·2022· 11 citedOpen Access
CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7
2021· 7 cited
Decision letter: Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
2021Open Access
A proximity-dependent biotinylation map of a human cell
Nature·2021· 470 citedOpen Access
Proximity‐Dependent Sensors Reveal New Mechanisms of mTORC1 Activation by Amino Acids
The FASEB Journal·2021
Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
Molecular Cell·2020· 46 cited
Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex
The Journal of Cell Biology·2020· 29 citedOpen Access
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Frequent Co-authors

Anne‐Claude Gingras(27), Gordon F. Tomaselli(11), David A. Kass(6), David Ginsburg(6), Jennifer E. Van Eyk(5), J. Paul Luzio(5), Seyed Mehdi Jafarnejad(5), Nahum Sonenberg(5), Takeshi Aiba(4), Fadi G. Akar(4), Manish H. Shah(4), David J. Owen(4), Tommy Alain(4), Thomas F. Duchaîne(4), James W. Dennis(4), Christopher D. Go(3), James D.R. Knight(3), Ji‐Young Youn(3), Payman Samavarchi‐Tehrani(3), Dushyandi Rajendran(3)