Tommy Alain

Agricultural Research Institute of Ontario — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

48h-index8.9kcitations201works4.72yr avg
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Research Topics

Virus-based gene therapy research(78), interferon and immune responses(41), PI3K/AKT/mTOR signaling in cancer(34), CAR-T cell therapy research(30), Viral gastroenteritis research and epidemiology(20)

Publications201 total

PP359 Oral oncolytic reovirus as a novel cancer vaccine strategy
ESMO Open·2026Open Access
Enhanced glioblastoma immunotherapy via SMAC mimetic dose escalation and TGFβ blockade
Neuro-Oncology Advances·2025Open Access
Reovirus oncolysis and the next frontiers for this unique oncoviral immunotherapy
Seminars in Immunology·2025
Oncolytic viruses in action: A successful unique case to be considered with caution
Virologie·2025Open Access
Oncolytic viruses in action: A successful unique case to be considered with caution
Virologie·2025
RSK1 and RSK2 modulate the translatome of glioblastoma cells in an isoform-specific and mTORC1 independent manner
Neuro-Oncology Advances·2025Open Access
The 16th Annual International Oncolytic Virotherapy Conference (IOVC) in Rotterdam: For the dreamers and doers of oncolytic virotherapy
Virologie·2025
Ultrasound and Microbubble Mediated Delivery of Virus-Sensitizing Drugs Improves In Vitro Oncolytic Virotherapy Against Breast Cancer Cells
Ultrasound in Medicine & Biology·2025· 5 citedOpen Access
The 16th Annual International Oncolytic Virotherapy Conference (IOVC) in Rotterdam: For the dreamers and doers of oncolytic virotherapy
Virologie·2025
Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Nature Communications·2024Open Access
Antibiotic-mediated selection of randomly mutagenized and cytokine-expressing oncolytic viruses
Nature Biomedical Engineering·2024· 5 cited
The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer
Nature Communications·2024· 20 citedOpen Access
Ribosome Quality Control mitigates the cytotoxicity of ribosome collisions induced by 5-Fluorouracil
Nucleic Acids Research·2024· 11 citedOpen Access
Leukemia inhibitory factor drives transcriptional programs that promote lipid accumulation and M2 polarization in macrophages
Journal of Leukocyte Biology·2024· 5 citedOpen Access
Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds
Cell Death and Disease·2024· 13 citedOpen Access
Loss of Dnajc21 leads to cytopenia and altered nucleotide metabolism in zebrafish
Leukemia·2024· 3 citedOpen Access
Repression of mRNA translation initiation by GIGYF1 via disrupting the eIF3-eIF4G1 interaction
Science Advances·2024· 7 citedOpen Access
The reovirus variant RP116 is oncolytic in immunocompetent models and generates reduced neutralizing antibodies to Type 3 Dearing
Molecular Therapy Oncology·2024· 2 citedOpen Access
Tepilamide Fumarate as a Novel Potentiator of Virus-Based Therapy
Viruses·2024· 3 citedOpen Access
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Frequent Co-authors

Nahum Sonenberg(23), Ola Larsson(11), Ivan Topisirović(11), Tyson E. Graber(9), Masahiro Morita(8), Peter Forsyth(8), Bruno D. Fonseca(6), Emmanuel Petroulakis(6), Huy‐Dung Hoang(6), John C. Bell(6), Donna L. Senger(6), Valentina Gandin(5), Bruno D. Fonseca(5), Christos G. Gkogkas(5), Arkady Khoutorsky(5), Chadi Zakaria(4), Shannon McLaughlan(4), Patrick M. D’Aoust(4), Élisabeth Mercier(4), Mark R. Servos(4)