Chadi Zakaria

Jewish General Hospital — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index1.4kcitations10works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(4), DNA Repair Mechanisms(3), Metabolism, Diabetes, and Cancer(3), interferon and immune responses(3), Virus-based gene therapy research(2)

Publications10 total

Molecular targeting of the UDP-glucuronosyltransferase enzymes in high-eukaryotic translation initiation factor 4E refractory/relapsed acute myeloid leukemia patients: a randomized phase II trial of vismodegib, ribavirin with or without decitabine
Haematologica·2023· 12 citedOpen Access
Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis
PLoS Pathogens·2018· 31 citedOpen Access
Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells
Oncotarget·2016· 26 citedOpen Access
S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3
Nature Immunology·2016· 82 citedOpen Access
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
Journal of Biological Chemistry·2015· 268 citedOpen Access
Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing
Nature Communications·2015· 68 citedOpen Access
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Cell Metabolism·2013· 817 citedOpen Access
The endonuclease IV family of apurinic/apyrimidinic endonucleases
Mutation Research/Reviews in Mutation Research·2010· 59 cited
Caenorhabditis elegans APN-1 plays a vital role in maintaining genome stability
DNA repair·2009· 26 cited
The in vivo characterization of the DNA repair gene apn-1 in the model organism Caenorhabditis elegans
Papyrus : Institutional Repository (Université de Montréal)·2009Open Access

Frequent Co-authors

Tommy Alain(6), Nahum Sonenberg(5), Masahiro Morita(3), Tyson E. Graber(3), Huy‐Dung Hoang(3), Akiko Yanagiya(3), Michaël Pollak(2), Bruno D. Fonseca(2), Soroush Tahmasebi(2), Jaclyn Hearnden(2), Karen Mossman(2), Fabrice Le Bœuf(2), John C. Bell(2), Jean‐Simon Diallo(2), Dindial Ramotar(2), Maritza Jaramillo(2), Simon‐Pierre Gravel(1), Valérie Chénard(1), Kristina Sikström(1), Liang Zheng(1)