Isar Nassiri

Centre for Human Genetics — United Kingdom

Medicine · Health Sciences

16h-index1.8kcitations52works5.62yr avg
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Research Topics

Cancer Immunotherapy and Biomarkers(16), Immune Cell Function and Interaction(10), Single-cell and spatial transcriptomics(8), CAR-T cell therapy research(8), Bioinformatics and Genomic Networks(7)

Publications48 total

Genetic determinants of monocyte splicing are enriched for disease susceptibility loci
Nature Communications·2025Open Access
CMV serostatus is associated with improved survival and delayed toxicity onset following anti-PD-1 checkpoint blockade
Nature Medicine·2025· 13 citedOpen Access
Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms
Nature Communications·2025· 24 citedOpen Access
Cytomegalovirus infection protects against metastatic melanoma and modulates oncological outcome and toxicity to checkpoint immunotherapy
2024Open Access
Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19
2024Open Access
An isoform quantitative trait locus in SBNO2 links genetic susceptibility to Crohn’s disease with defective antimicrobial activity
Nature Communications·2024· 2 citedOpen Access
Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes
Cell Genomics·2024· 4 citedOpen Access
Peripheral monocyte transcriptomics associated with immune checkpoint blockade outcomes in metastatic melanoma
2024Open Access
Demultiplexing of single-cell RNA-sequencing data using interindividual variation in gene expression
Bioinformatics Advances·2024· 7 citedOpen Access
Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments
2023· 4 citedOpen Access
A role for SETD2 loss in tumorigenesis through DNA methylation dysregulation
BMC Cancer·2023· 7 citedOpen Access
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Nature·2023· 10 citedOpen Access
scQCEA: a framework for annotation and quality control report of single-cell RNA-sequencing data
BMC Genomics·2023· 4 citedOpen Access
Characterisation of the genetic determinants of context specific DNA methylation in primary monocytes
2023Open Access
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Nature·2023· 182 citedOpen Access
Deep sequencing of the T cell Receptor reveals common and reproducible CD8 <sup>+</sup> signatures of response to checkpoint immunotherapy
2023· 2 citedOpen Access
Additional file 2 of scQCEA: a framework for annotation and quality control report of single-cell RNA-sequencing data
Figshare·2023Open Access
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
Nature Medicine·2022· 68 citedOpen Access
Genetic variation at IL7 provides mechanistic insights into toxicity to immune checkpoint blockade
Research Square (Research Square)·2022· 3 citedOpen Access
An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
Nature Immunology·2021· 180 citedOpen Access
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Frequent Co-authors

Benjamin P. Fairfax(36), Chelsea Taylor(22), Mark R. Middleton(16), Orion Tong(16), Robert Watson(15), Sara Danielli(15), Rosalin Cooper(15), Julian C. Knight(14), Piyush Kumar Sharma(12), James J. Gilchrist(12), Hussein Al‐Mossawi(10), Miranda Payne(9), Alba Verge de los Aires(9), Elise A. Mahé(8), Weiyu Ye(8), Paul Klenerman(7), Nicholas Coupe(7), Victoria K. Woodcock(6), Bo Sun(6), Evelyn Lau(6)