Helen Sanger

Eli Lilly (United Kingdom) — United Kingdom

Neuroscience · Life Sciences

11h-index547citations16works5.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(12), Receptor Mechanisms and Signaling(6), Nicotinic Acetylcholine Receptors Study(3), Alzheimer's disease research and treatments(2), Molecular Sensors and Ion Detection(2)

Publications16 total

Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318
Pain·2025· 5 citedOpen Access
The atypical ‘hippocampal’ glutamate receptor coupled to phospholipase D that controls stretch‐sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental Physiology·2023· 15 citedOpen Access
Metabotropic Glutamate Receptors Modulate Exocytotic Tau Release and Propagation
Journal of Pharmacology and Experimental Therapeutics·2022· 11 citedOpen Access
How early is early? When should rehabilitation begin in critical illness?
Journal of the Association of Chartered Physiotherapists in Respiratory Care·2020
Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M <sub>1</sub> receptors
British Journal of Pharmacology·2018· 13 citedOpen Access
Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes
Molecular Pharmacology·2018· 29 citedOpen Access
In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography
Journal of Pharmacology and Experimental Therapeutics·2018· 11 citedOpen Access
Current status of muscarinic M1 and M4 receptors as drug targets for neurodegenerative diseases
Neuropharmacology·2018· 87 cited
[O1–07–05]: REGULATED RELEASE OF HYPER‐PHOSPHORYLATED, AGGREGATED AND SEEDING COMPETENT TAU FROM RODENT BRAINS AND HUMAN SYNAPTOSOMES
Alzheimer s & Dementia·2017
Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a
Psychopharmacology·2017· 25 cited
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss
Journal of Clinical Investigation·2016· 78 citedOpen Access
In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu 2/3 receptor antagonist
Neuropharmacology·2015· 22 cited
Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
Cerebral Cortex·2015· 141 citedOpen Access
Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1<i>S</i>,2<i>S</i>,5<i>R</i>,6<i>S</i>-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures
Journal of Medicinal Chemistry·2015· 59 cited
Pharmacological profiling of the <scp>TRPV3</scp> channel in recombinant and native assays
British Journal of Pharmacology·2013· 21 citedOpen Access
Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR
Neuropharmacology·2012· 30 cited

Frequent Co-authors

Lisa M. Broad(13), Adrian J. Mogg(7), Christian C. Felder(6), James A. Monn(5), Olivera Grubisha(5), Francesca Pasqui(4), Ellen M. Colvin(4), Paul Goldsmith(4), Beverly A. Heinz(4), Emanuele Sher(4), Daniel Ursu(3), Stephen M. Fitzjohn(2), David A. Evans(2), Sophie J. Bradley(2), Colin Molloy(2), Patrick M. Sexton(2), Arthur Christopoulos(2), Andrew B. Tobin(2), Joan H. Carter(2), Chuanxi Xiang(2)