Patrick M. Sexton

Australian Research Council — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

89h-index30.4kcitations1.7kworks4.52yr avg
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Research Topics

Receptor Mechanisms and Signaling(367), Neuropeptides and Animal Physiology(279), Diabetes Treatment and Management(75), Neuroscience and Neuropharmacology Research(51), Monoclonal and Polyclonal Antibodies Research(44)

Publications846 total

Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Contrasting roles for GLP-1R and GIPR in a model of diet-induced obesity
Journal of Molecular Endocrinology·2025
Cholesterol residence time drives regulation of the G protein-coupled cholecystokinin receptor
Molecular Pharmacology·2025
A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles
Nature Nanotechnology·2025· 11 citedOpen Access
1974-LB: The Molecular Basis of Survodutide (BI456906) Glucagon/GLP-1 Receptor Dual Agonism
Diabetes·2025
Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors
Biochemistry·2025· 2 cited
Design of peptide-based PAC1 antagonists combining molecular dynamics simulations and a biologically relevant cell-based assay
2025Open Access
Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors
Nature Communications·2025· 8 citedOpen Access
Cryoelectron microscopy as a tool for illuminating activation mechanisms of human class A orphan G protein-coupled receptors
Pharmacological Reviews·2025· 4 cited
Prolonged signaling of backbone-modified glucagon‐like peptide‐ <b>1</b> analogues with diverse receptor trafficking
Proceedings of the National Academy of Sciences·2025· 4 citedOpen Access
Native adenosine A <sub>2A</sub> receptor solubilisation by a library of amphipathic copolymers
Biomaterials Science·2025
Correction: Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors
The Journal of General Physiology·2024Open Access
<i>In vivo</i> functional profiling and structural characterisation of the human <i>Glp1r</i> A316T variant
2024· 1 citedOpen Access
Isoquinoline small molecule ligands are agonists and probe-dependent allosteric modulators of the glucagon subfamily of GPCRs
Biochemical Pharmacology·2024· 1 citedOpen Access
Porous Silicon Microparticles Enable Sustained Release of GLP‐1R Agonist Peptides for the Treatment of Type 2 Diabetes
Advanced Therapeutics·2024· 5 citedOpen Access
A Versatile Antibody Capture System that Drives Precise <i>In Viv</i> o Delivery of mRNA loaded Lipid Nanoparticles and Enhances Gene Expression
2024· 3 citedOpen Access
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
PLoS Biology·2024· 3 citedOpen Access
Impact of secretin receptor homo-dimerization on natural ligand binding
Nature Communications·2024· 3 citedOpen Access
PACAP(6-38) Deletants as Peptide-based PACAP Antagonists
Journal of Pharmacology and Experimental Therapeutics·2024· 1 cited
Prolonged signaling of backbone-modified glucagon-like peptide-1 analogues with diverse receptor trafficking
2024Open Access
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Frequent Co-authors

Arthur Christopoulos(40), Denise Wootten(14), Alisa Glukhova(9), Laurence J. Miller(9), Céline Valant(8), David M. Thal(7), Yi-Lynn Liang(6), Sebastian G. B. Furness(6), Radostin Danev(6), Brian K. Kobilka(5), Lauren T. May(5), Katie Leach(5), George Christopoulos(5), J. Robert Lane(5), Maryam Khoshouei(4), Wolfgang Baumeister(4), Peter J. Scammells(4), Peishen Zhao(4), Cassandra Koole(4), Wiepke Cahn(4)