Céline Valant

Australian Research Council — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index5.4kcitations108works2.32yr avg
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Research Topics

Receptor Mechanisms and Signaling(95), Neuropeptides and Animal Physiology(48), Neuroscience and Neuropharmacology Research(24), Nicotinic Acetylcholine Receptors Study(18), Pharmacological Receptor Mechanisms and Effects(18)

Publications106 total

Structure-guided allosteric modulation of the delta opioid receptor
2025Open Access
Acetylcholine receptors (muscarinic) in GtoPdb v.2025.3
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
UNC Libraries·2025Open Access
Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR
Nature Communications·2025· 1 citedOpen Access
A Structure–Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor
ACS Chemical Neuroscience·2025· 2 cited
The Prosperity and Adversity of M<sub>4</sub> Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders
Journal of Medicinal Chemistry·2025
Cryo-EM reveals a new allosteric binding site at the M <sub>5</sub> mAChR
2025· 1 citedOpen Access
Positive allosteric modulation of a GPCR ternary complex
Science Advances·2024· 9 citedOpen Access
Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges
Neuropharmacology·2024· 12 citedOpen Access
Discovery of 2-Methyl-5-(1<i>H</i>-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M<sub>4</sub> mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Journal of Medicinal Chemistry·2024
Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice
Brain Behavior and Immunity·2024· 2 citedOpen Access
Positive allosteric modulation of a GPCR ternary complex
2024· 1 citedOpen Access
Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways
Biochemical Pharmacology·2023· 3 citedOpen Access
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Nature Communications·2023· 33 citedOpen Access
Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
European Journal of Medicinal Chemistry·2023· 3 citedOpen Access
Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor
Molecular Pharmacology·2023· 5 citedOpen Access
Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1
IUPHAR/BPS Guide to Pharmacology CITE·2023· 3 citedOpen Access
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
eLife·2023· 33 citedOpen Access
Author response: Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
2023· 1 citedOpen Access
Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs
Nature Chemical Biology·2023· 3 citedOpen Access
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Frequent Co-authors

Arthur Christopoulos(47), Patrick M. Sexton(40), Peter J. Scammells(19), David M. Thal(8), Emma T. van der Westhuizen(8), Luigi Aurelio(8), Andrew B. Tobin(7), Christian C. Felder(6), Denise Wootten(6), Geoff Thompson(6), Ben Capuano(6), Vi Pham(6), J. Robert Lane(5), Lauren T. May(5), Bernard L. Flynn(5), Wessel A. C. Burger(5), Ron O. Dror(4), Paul J. White(4), Ziva Vuckovic(4), Christopher J. Langmead(4)