Luigi Aurelio

Monash University — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index2.4kcitations55works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(12), Receptor Mechanisms and Signaling(12), Adenosine and Purinergic Signaling(10), Neuropeptides and Animal Physiology(8), Catalytic C–H Functionalization Methods(5)

Publications55 total

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain
Biomaterials·2022· 42 citedOpen Access
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes
Journal of Biological Chemistry·2021· 26 citedOpen Access
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells
Nature Communications·2020· 34 citedOpen Access
Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes
ACS Chemical Biology·2020· 24 citedOpen Access
Granzyme A in Chikungunya and Other Arboviral Infections
Frontiers in Immunology·2020· 42 citedOpen Access
SNAP <sub>Switch</sub> : A Molecular Sensor to Quantify the Localization of Proteins, DNA and Nanoparticles in Cells
2019Open Access
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease
Scientific Reports·2019· 28 citedOpen Access
Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents
Journal of Medicinal Chemistry·2018· 22 cited
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
Proceedings of the National Academy of Sciences·2018· 175 citedOpen Access
Quantifying Cellular Internalization with a Fluorescent Click Sensor
ACS Sensors·2018· 26 citedOpen Access
A Structure–Activity Relationship Study of Bitopic<i>N</i><sup>6</sup>-Substituted Adenosine Derivatives as Biased Adenosine A<sub>1</sub>Receptor Agonists
Journal of Medicinal Chemistry·2018· 33 citedOpen Access
8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Chemistry - A European Journal·2017· 55 cited
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
Proceedings of the National Academy of Sciences·2017· 180 citedOpen Access
Selective Distance Measurements Using Triple Spin Labeling with Gd<sup>3+</sup>, Mn<sup>2+</sup>, and a Nitroxide
The Journal of Physical Chemistry Letters·2017· 49 cited
Chemical Tagging with <i>tert</i>‐Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein–Ligand Complex
Chemistry - A European Journal·2017· 13 cited
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Science Translational Medicine·2017· 236 citedOpen Access
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation
Bioorganic & Medicinal Chemistry Letters·2016· 31 citedOpen Access
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity
Molecular Pharmacology·2016· 58 cited
Legumain is activated in macrophages during pancreatitis
American Journal of Physiology-Gastrointestinal and Liver Physiology·2016· 44 citedOpen Access
Sphingolipid Targeting Agent MIPS247 Attenuates Collagen Synthesis by Cardiac and Kidney Cells via Stabilisation of PPM1A
Heart Lung and Circulation·2016Open Access
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Frequent Co-authors

Peter J. Scammells(17), Bernard L. Flynn(15), Andrew B. Hughes(14), Robert T. C. Brownlee(9), Nigel W. Bunnett(9), Céline Valant(9), Patrick M. Sexton(9), Arthur Christopoulos(9), Bim Graham(9), Daniel P. Poole(6), Nicholas A. Veldhuis(5), Laura E. Edgington‐Mitchell(5), Dane D. Jensen(4), Michelle L. Halls(4), Christopher J. H. Porter(4), Meritxell Canals(4), Paul J. White(4), Luke A. Adams(4), Gottfried Otting(4), TinaMarie Lieu(3)