Nathalie Méthot

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.7kcitations40works0.02yr avg
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Research Topics

RNA Research and Splicing(9), RNA and protein synthesis mechanisms(8), Nicotinic Acetylcholine Receptors Study(6), RNA regulation and disease(6), Protease and Inhibitor Mechanisms(5)

Publications40 total

Responsible and Ethical Conduct of College Research, a guide
Bibliothèque et Archives nationales du Québec (Québec government)·2021Open Access
Conduite responsable et éthique de la recherche collégiale, le guide
Bibliothèque et Archives nationales du Québec (Québec government)·2021Open Access
Conduite responsable et éthique de la recherche collégiale, le didacticiel
2021
Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure
Antimicrobial Agents and Chemotherapy·2013· 103 citedOpen Access
Trisubstituted ureas as potent and selective mPGES-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 23 citedOpen Access
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease
Bioorganic & Medicinal Chemistry Letters·2010· 70 citedOpen Access
Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]
Bioorganic & Medicinal Chemistry Letters·2010· 2 cited
Évaluation de l'Initiative ciblée pour les travailleurs âgés (ICTA) - volet formatif [ressource électronique] : entrevues avec des représentantes et des représentants d'Emploi-Québec et d'organismes promoteurs de projet ICTA
2010
Corrigendum to “Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C” [Bioorg. Med. Chem. Lett. 19 (2009) 5392]
Bioorganic & Medicinal Chemistry Letters·2009
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 61 citedOpen Access
Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C
Bioorganic & Medicinal Chemistry Letters·2009· 42 citedOpen Access
MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Journal of Pharmacology and Experimental Therapeutics·2008· 151 cited
In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C
Molecular Pharmacology·2008· 53 cited
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 128 citedOpen Access
Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing
Journal of Biological Chemistry·2007· 77 citedOpen Access
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886
Bioorganic & Medicinal Chemistry Letters·2005· 142 citedOpen Access
A Caspase Active Site Probe Reveals High Fractional Inhibition Needed to Block DNA Fragmentation
Journal of Biological Chemistry·2004· 23 citedOpen Access
Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile
Journal of Biological Chemistry·2004· 118 citedOpen Access
Differential Efficacy of Caspase Inhibitors on Apoptosis Markers during Sepsis in Rats and Implication for Fractional Inhibition Requirements for Therapeutics
The Journal of Experimental Medicine·2004· 53 citedOpen Access
Structure of the Pore-forming Transmembrane Domain of a Ligand-gated Ion Channel
Journal of Biological Chemistry·2001· 33 citedOpen Access
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Frequent Co-authors

Diane Ethier(10), Nahum Sonenberg(9), Joel Rubin(9), Denis Riendeau(8), Christian Beaulieu(7), Joseph A. Mancini(6), M. David Percival(6), John E. Baenziger(6), Sébastien Guiral(5), Richard W. Friesen(5), Frédéric Massé(5), Daniel Guay(5), T. Jagadeeswar Reddy(5), Robert Zamboni(5), Arnim Pause(4), Konrad Basler(4), Daigen Xu(4), André Giroux(4), Bernard Côté(4), Yves Ducharme(4)