David Sumpton

Cancer Research UK — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index4.2kcitations151works8.52yr avg
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Research Topics

Cancer, Hypoxia, and Metabolism(30), Prostate Cancer Treatment and Research(23), Cancer, Lipids, and Metabolism(20), Mass Spectrometry Techniques and Applications(13), PARP inhibition in cancer therapy(13)

Publications151 total

Thiol Scarcity in Cerebrospinal Fluid Renders Leptomeningeal Acute Lymphoblastic Leukaemia Therapeutically Vulnerable to Ferroptosis
2025Open Access
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Nature Communications·2025Open Access
NADPH controls a cell state vulnerability towards ferroptosis in acute lymphoblastic leukaemia
Blood·2025Open Access
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics·2025· 3 citedOpen Access
SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis
Molecular Cell·2025· 5 citedOpen Access
The AMPK-related kinase NUAK1 regulates neuronal morphogenesis through the RNA splicing co-factor SON
2025Open Access
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
Science Advances·2025· 1 citedOpen Access
P3.14.08 Genetically Defined Mouse Models of Malignant Pleural Mesothelioma Recapitulate Human MPM Phenotypes and Response to Therapy
Journal of Thoracic Oncology·2025
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes
EMBO Reports·2025· 3 citedOpen Access
Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments
The Journal of Cell Biology·2025· 2 citedOpen Access
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
2025Open Access
Increased mRNA translation delays lung adenocarcinoma initiation and exposes a therapeutic vulnerability to MEK inhibitors
2025Open Access
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
2025Open Access
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
Cancer Discovery·2025· 3 citedOpen Access
Data from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
2025Open Access
List of Consortium Members from Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta
2025Open Access
Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ
Nature Cell Biology·2024· 44 citedOpen Access
Colibactin-driven colon cancer requires adhesin-mediated epithelial binding
Nature·2024· 46 citedOpen Access
Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
EMBO Molecular Medicine·2024· 13 citedOpen Access
The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapy
2024Open Access
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Frequent Co-authors

Gillian Mackay(16), Colin Nixon(15), Sara Zanivan(12), Karen Blyth(11), Owen J. Sansom(11), Johan Vande Voorde(9), Sérgio Lilla(9), Saverio Tardito(8), Giovanny Rodriguez Blanco(8), William Clark(6), Jurre J. Kamphorst(6), Alexei Vázquez(6), Ann Hedley(5), Andrew D. Campbell(5), Hing Y. Leung(5), Louise Mitchell(5), Jane Thomas‐Oates(5), Eyal Gottlieb(4), Willy V. Bienvenut(4), Catriona A. Ford(4)