Pedro A. Lazo

Instituto de Investigación Biomédica de Salamanca — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

53h-index16.6kcitations220works2.02yr avg
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Research Topics

Nuclear Structure and Function(62), Cancer-related Molecular Pathways(38), Virus-based gene therapy research(34), Microtubule and mitosis dynamics(23), RNA Research and Splicing(23)

Publications215 total

VRK2 kinase pathogenic pathways in cancer and neurological diseases
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2025Open Access
Nuclear functions regulated by the VRK1 kinase
Nucleus·2024· 1 citedOpen Access
VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells
International Journal of Molecular Sciences·2024· 3 citedOpen Access
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy
Journal of Molecular Medicine·2024· 2 citedOpen Access
Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin
Chemico-Biological Interactions·2024· 4 citedOpen Access
VRK1 variants at the cross road of Cajal body neuropathogenic mechanisms in distal neuropathies and motor neuron diseases
Neurobiology of Disease·2023· 12 citedOpen Access
The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase
Epigenetics & Chromatin·2023· 13 citedOpen Access
VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1
International Journal of Molecular Sciences·2023· 38 citedOpen Access
The VRK1 chromatin kinase regulates the acetyltransferase activity of Tip60/KAT5 by sequential phosphorylations in response to DNA damage
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms·2022· 37 citedOpen Access
Targeting Histone Epigenetic Modifications and DNA Damage Responses in Synthetic Lethality Strategies in Cancer?
Cancers·2022· 17 citedOpen Access
Lysine Methyltransferase Inhibitors Impair H4K20me2 and 53BP1 Foci in Response to DNA Damage in Sarcomas, a Synthetic Lethality Strategy
Frontiers in Cell and Developmental Biology·2021· 1 citedOpen Access
Dysfunctional Homozygous VRK1-D263G Variant Impairs the Assembly of Cajal Bodies and DNA Damage Response in Hereditary Spastic Paraplegia
Neurology Genetics·2021· 9 citedOpen Access
VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells
Frontiers in Cell and Developmental Biology·2021· 47 citedOpen Access
Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome
Human Genomics·2021· 8 citedOpen Access
The human VRK1 chromatin kinase in cancer biology
Cancer Letters·2021· 79 citedOpen Access
Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome
Research Square (Research Square)·2021Open Access
Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome
2020Open Access
VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage
Cancers·2020· 58 citedOpen Access
Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome
International Journal of Molecular Sciences·2020· 9 citedOpen Access
VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy
Annals of Clinical and Translational Neurology·2020· 17 citedOpen Access
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Frequent Co-authors

Sandra Blanco(12), Marta Sanz-García(11), Francisco M. De La Vega(10), Alberto Valbuena(8), Ana Sevilla(6), Ignacio Campillo‐Marcos(6), Marta Vázquez-Cedeira(5), Cláudio R. Santos(5), Inmaculada López-Sánchez(4), Marcella Salzano(4), Diana M. Monsalve(4), Isabel F. Fernández(4), Mónica Yunta(3), Ramiro Barcia(3), Montse Sánchez‐Céspedes(3), Susana López-Borges(2), Laia Simó‐Riudalbas(2), Cátia Moutinho(2), Sebastián Morán(2), Alberto Villanueva(2)