Jérôme Mertens

Salk Institute for Biological Studies — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index7.2kcitations64works22.62yr avg
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Research Topics

Pluripotent Stem Cells Research(28), Alzheimer's disease research and treatments(10), Neurogenesis and neuroplasticity mechanisms(10), CRISPR and Genetic Engineering(10), Mitochondrial Function and Pathology(8)

Publications64 total

Reprogramming Stars #25: Modeling Brain Aging with Direct Reprogramming of Skin Cells into Neurons—An Interview with Dr. Jerome Mertens
Cellular Reprogramming·2025
An accelerated human in-vitro aging model mimics in-vivo aging and facilitates dynamic testing of anti-aging compounds
2025Open Access
Studying APOE Aggregation in Live Cells and Human Neurons
Alzheimer s & Dementia·2024Open Access
All roads lead to cholesterol: Modulating lipid biosynthesis in multiple sclerosis patient-derived models
Cell stem cell·2024· 2 citedOpen Access
Neuronal senescence may drive brain aging
Science·2024· 49 citedOpen Access
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia
Molecular Psychiatry·2024· 6 citedOpen Access
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK
Cell Metabolism·2024· 109 citedOpen Access
Ignorance is bliss: Inhibition of proteomic stress sensing improves direct neuronal conversion
Neuron·2024
Cellular reprogramming as a tool to model human aging in a dish
Nature Communications·2024· 37 citedOpen Access
Age‐equivalent induced neurons from patients reveal neuronal fate loss and metabolic transformation underlying neurodegeneration in sporadic Alzheimer’s disease
Alzheimer s & Dementia·2023· 2 citedOpen Access
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy
Cells·2023· 2 citedOpen Access
Neural cell state shifts and fate loss in ageing and age-related diseases
Nature Reviews Neurology·2023· 27 citedOpen Access
Novel therapeutic approaches to target neurodegeneration
British Journal of Pharmacology·2023· 26 citedOpen Access
Novel therapeutic approaches to target neurodegeneration
2022· 1 citedOpen Access
Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia.
Research Square (Research Square)·2022Open Access
Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease
Cell stem cell·2022· 170 citedOpen Access
Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons
npj Parkinson s Disease·2022· 18 citedOpen Access
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease
Cell Metabolism·2022· 163 citedOpen Access
Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion
Cellular Reprogramming·2022· 4 citedOpen Access
Metabolism navigates neural cell fate in development, aging and neurodegeneration
Disease Models & Mechanisms·2021· 43 citedOpen Access
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Frequent Co-authors

Fred H. Gage(22), Joseph R. Herdy(13), Larissa Traxler(9), Yongsung Kim(8), Simon T. Schafer(8), Philipp Koch(8), Apuã C.M. Paquola(7), Manching Ku(7), Oliver Brüstle(7), Lena Böhnke(6), Leah Boyer(6), Maria C. Marchetto(6), Hyungjun Lee(5), Julia Ladewig(5), Christopher K. Glass(5), Johannes C. M. Schlachetzki(5), Frank Edenhofer(5), Tomohisa Toda(4), Jun Yao(4), Son Pham(4)