Hideki Uosaki

Jichi Medical University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index2.9kcitations69works0.52yr avg
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Research Topics

Pluripotent Stem Cells Research(28), Congenital heart defects research(28), CRISPR and Genetic Engineering(18), Tissue Engineering and Regenerative Medicine(12), RNA Research and Splicing(9)

Publications69 total

Transcriptome-based maturation assessment revealed pro-maturation transcription factors of cardiomyocytes
Frontiers in Bioengineering and Biotechnology·2026Open Access
ATM Inhibition Enhances Knock-in Efficiency by Suppressing AAV-Induced Activation of Apoptotic Pathways
Communications Biology·2026Open Access
Targeting the undruggable transcription factor, KLF5, with a peptidomimetic small molecule, NC114, attenuates pressure overload-induced cardiac remodeling and fibrosis
Scientific Reports·2026Open Access
Disease modeling of restrictive cardiomyopathy to identify a new therapy
European Heart Journal·2025
Abstract Thu023: Inter-Organ Comparison Identifies Shared MicroRNAs during Maturation
Circulation Research·2025
Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM)
JACC CardioOncology·2025· 3 citedOpen Access
Abstract 11841: Gene Therapy Improves Pathological Cardiac Remodeling in Human Hypertrophic Cardiomyopathy Gene Variant Knock-In Mice
Circulation·2023· 1 cited
PB0165 Gene Correction of Human Hemophilia B Mutation by PAM-Flexible Cas9-Mediated Base-Editing Approach
Research and Practice in Thrombosis and Haemostasis·2023Open Access
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis
Cell·2023· 100 citedOpen Access
PAM-flexible Cas9-mediated base editing of a hemophilia B mutation in induced pluripotent stem cells
Communications Medicine·2023· 24 citedOpen Access
Cardiac progenitors instruct second heart field fate through Wnts
Proceedings of the National Academy of Sciences·2023· 16 citedOpen Access
Total and reduced/oxidized forms of coenzyme Q10 in fibroblasts of patients with mitochondrial disease
Molecular Genetics and Metabolism Reports·2023· 11 citedOpen Access
Reifung von aus pluripotenten Stammzellen gewonnenen Kardiomyozyten und Zukunftsperspektiven für die regenerative Medizin
2023
Hormone and nuclear receptor activations are required for cardiomyocyte maturation
Journal of Molecular and Cellular Cardiology·2022
Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles
Philosophical Transactions of the Royal Society B Biological Sciences·2022· 43 citedOpen Access
Prolonged Myocardial Regenerative Capacity in Neonatal Opossum
Circulation·2022· 34 citedOpen Access
Cross-Organ Transcriptomic Comparison Reveals Universal Factors During Maturation
Journal of Computational Biology·2022· 3 citedOpen Access
Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation
iScience·2022· 14 citedOpen Access
Sympathetic Neurons Regulate Cardiomyocyte Maturation in Culture
Frontiers in Cell and Developmental Biology·2022· 36 citedOpen Access
Disease Modeling of Mitochondrial Cardiomyopathy Using Patient-Specific Induced Pluripotent Stem Cells
Biology·2021· 7 citedOpen Access
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Frequent Co-authors

Chulan Kwon(15), Peter Andersen(10), Nawin Chanthra(9), Yutaka Hanazono(9), Jun K. Yamashita(8), Tatsuya Anzai(8), Matthew Miyamoto(8), Sean Murphy(8), Takeshi Tokuyama(7), David A. Kass(6), Emmanouil Tampakakis(6), Genta Narazaki(5), Satoshi Matsuoka(5), Razan E. Ahmed(5), Suraj Kannan(5), Osamu Nureki(5), Hiromasa Hara(5), Hiroyuki Fukushima(4), Nozomu Yachie(4), Tsukasa Ohmori(4)