Yan Yi Chen

Biochemistry, Genetics and Molecular Biology · Life Sciences

7h-index595citations12works10.52yr avg
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Research Topics

CRISPR and Genetic Engineering(7), CAR-T cell therapy research(7), T-cell and B-cell Immunology(2), Immune Cell Function and Interaction(2), MicroRNA in disease regulation(1)

Publications12 total

Abstract PR008: CD4+ T cell rest and activation is enabled by centralized control of state specific regulatory genes
Cancer Immunology Research·2025
Central control of dynamic gene circuits governs T cell rest and activation
Nature·2024· 21 citedOpen Access
Base-editing mutagenesis maps alleles to tune human T cell functions
Nature·2023· 80 citedOpen Access
Modular pooled discovery of synthetic knockin sequences to program durable cell therapies
Cell·2023· 61 citedOpen Access
Highly Parallel Discovery of Synthetic Knockin Sequences for Enhanced Cancer Immunotherapies
Blood·2022
High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails
Nature Biotechnology·2022· 206 citedOpen Access
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
Nature·2022· 203 citedOpen Access
Modular Pooled Discovery of Synthetic Knockin Sequences to Program Durable Cell Therapies
2022· 7 citedOpen Access
Hybrid ssDNA repair templates enable high yield genome engineering in primary cells for disease modeling and cell therapy manufacturing
2021· 16 citedOpen Access
Effect of DR microRNA biomarkers on angiogenesis assay activity in vitro
Investigative Ophthalmology & Visual Science·2019· 1 citedOpen Access
Research on the Layout of Integrated Freight Hub Based on Two-Stage Model
Advanced materials research·2014
Study on Classification of Transport Goods for its Transport Attributes Based on Quantitative Theory III
Applied Mechanics and Materials·2014

Frequent Co-authors

Alexander Marson(9), Justin Eyquem(7), Theodore L. Roth(6), Franziska Blaeschke(6), Brian R. Shy(5), Eric Shifrut(5), Ruby Yu(4), Julia Carnevale(4), William A. Nyberg(4), Zhongmei Li(4), Tobias Feuchtinger(4), Ansuman T. Satpathy(4), Chun Ye(4), Shane Vedova(3), Ralf Schmidt(3), Rama Dajani(3), Mineto Ota(3), Jonathan K. Pritchard(3), Ryan Apathy(3), Cody T. Mowery(3)