William J. Dower

Menlo School — United States

Medicine · Health Sciences

27h-index11.1kcitations57works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(30), Chemical Synthesis and Analysis(12), Glycosylation and Glycoproteins Research(11), Microbial Inactivation Methods(9), Immune Cell Function and Interaction(7)

Publications57 total

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy
PLoS ONE·2023· 6 citedOpen Access
A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy
2023· 1 citedOpen Access
1097 MDK1654: a branched synthetic peptide that activates both the IL-7 receptor and the βγc form of the IL-2/15 receptor
Regular and Young Investigator Award Abstracts·2022Open Access
Abstract 2066: In vitro and in vivo properties of MDK703: An Fc-peptide fusion IL-7Rαγc agonist unrelated in structure to IL-7
Cancer Research·2022
709 Peptidyl IL-2/15Rβγc-restricted agonists, highly-attenuated and linked to anti-PD-1 antibodies to achieve selectivity and amplified potency in stimulating PD-1high lymphocytes
Regular and Young Investigator Award Abstracts·2021· 3 citedOpen Access
566 MDK-202: An empirically-designed peptidyl agonist of the IL-2/15βγc receptor, devoid of Rα interaction, unrelated to IL-2 or IL-15, and fused to an Fc-domain for PK enhancement
Regular and Young Investigator Award Abstracts·2020Open Access
691 MDK-271: A dual function molecule consisting of empirically-designed peptidyl agonists of IL-2/15Rβγc and IL-7Rαγc, unrelated to IL-2, IL-15, or IL-7, incorporated into a bispecific Fc fusion protein
Regular and Young Investigator Award Abstracts·2020· 1 citedOpen Access
567 MDK1319/MDK-701: A potent fully efficacious peptidyl agonist of IL-7Rαγc, designed with no reference to cytokine or receptor structure and unrelated to IL-7, fused to an Fc-domain for PK enhancement
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
A potent synthetic dimeric peptide agonist of the erythropoietin receptor
Kluwer Academic Publishers eBooks·2005
Identiication of novel ligands for receptors using recombinant peptide libraries
2004
In Vitro Selection of Peptides Acting on NMDA Receptors
Humana Press eBooks·2003· 5 cited
Identification of Peptide Ligands for the Antigen Binding Receptor Expressed on Human B-Cell Lymphomas
Humana Press eBooks·2003· 1 cited
Expression of Extracellular N-Terminal Domain of NMDA Receptor in Mammalian Cells
Humana Press eBooks·2003· 1 cited
Synthetic Compound Libraries Displayed on the Surface of Encoded Bacteriophage
Chemistry & Biology·2003· 27 citedOpen Access
In vitro selection as a powerful tool for the applied evolution of proteins and peptides
Current Opinion in Chemical Biology·2002· 75 cited
A peptide mimetic of erythropoietin: Critical residues and description of a minimal functional epitope
2002
Targeting growth factor and cytokine receptors with recombinant peptide libraries
Current Opinion in Chemical Biology·1998· 18 cited
Peptide agonists of the thrombopoietin receptor
Stem Cells·1998· 24 citedOpen Access
Identification of a 13 Amino Acid Peptide Mimetic of Erythropoietin and Description of Amino Acids Critical for the Mimetic Activity of EMP1
Biochemistry·1998· 101 cited
Increased potency of an erythropoietin peptide mimetic through covalent dimerization
Nature Biotechnology·1997· 115 cited
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Frequent Co-authors

Ronald W. Barrett(20), Steven E. Cwirla(15), Mark A. Gallop(6), Stephen P. A. Fodor(5), Nicholas C. Wrighton(5), Praechompoo Pongtornpipat(5), Prarthana Joshi(5), Eric M. Gordon(4), Linda K. Jolliffe(4), Larry Mattheakis(4), Balasubramanian Palaniappan(4), Peter J. Schatz(4), Emily Tate(4), Erik A. Whitehorn(4), Alice Bakker(4), J. T. Trevors(4), Bruce M. Chassy(4), Hans P. Blaschek(4), Elizabeth A. Peters(3), Francis X. Farrell(3)