Jeremy H. Toyn

Bristol-Myers Squibb (United States) — United States

Medicine · Health Sciences

26h-index2.4kcitations59works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(26), Computational Drug Discovery Methods(20), Fungal and yeast genetics research(16), Cholinesterase and Neurodegenerative Diseases(14), Microtubule and mitosis dynamics(9)

Publications59 total

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite
Bioorganic & Medicinal Chemistry Letters·2020· 4 citedOpen Access
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
ACS Medicinal Chemistry Letters·2019· 22 citedOpen Access
Synergistic inhibition of Aβ production by combinations of γ-secretase modulators
European Journal of Pharmacology·2017· 4 cited
Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
Bioorganic & Medicinal Chemistry Letters·2016· 16 citedOpen Access
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors
Journal of Medicinal Chemistry·2016· 12 citedOpen Access
The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers
Journal of Pharmacology and Experimental Therapeutics·2016· 45 citedOpen Access
Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects
Journal of Pharmacology and Experimental Therapeutics·2016· 25 citedOpen Access
Synthesis of pyrimido[4,5-c]azepine- and pyrimido[4,5-c]oxepine-based γ-secretase modulators
Bioorganic & Medicinal Chemistry Letters·2016· 7 citedOpen Access
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
ACS Medicinal Chemistry Letters·2016· 30 citedOpen Access
Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)
Bioorganic & Medicinal Chemistry Letters·2015· 15 citedOpen Access
Design and optimization of tricyclic gamma-secretase modulators
Bioorganic & Medicinal Chemistry Letters·2015· 12 citedOpen Access
What lessons can be learned from failed Alzheimer’s disease trials?
Expert Review of Clinical Pharmacology·2015· 47 cited
Interpreting Alzheimer’s disease clinical trials in light of the effects on amyloid-β
Alzheimer s Research & Therapy·2014· 34 citedOpen Access
Identification and Preclinical Pharmacology of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">γ</mml:mi></mml:mrow></mml:math>-Secretase Modulator BMS-869780
International Journal of Alzheimer s Disease·2014· 13 citedOpen Access
<i>γ</i>-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
International Journal of Alzheimer s Disease·2013· 2 citedOpen Access
Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
Journal of Pharmacology and Experimental Therapeutics·2012· 63 cited
Acyl Guanidine Inhibitors of β-Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis
Journal of Medicinal Chemistry·2012· 48 citedOpen Access
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 14 citedOpen Access
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)
Bioorganic & Medicinal Chemistry Letters·2011· 20 citedOpen Access
Viable mouse gene ablations that robustly alter brain Aβ levels are rare
BMC Neuroscience·2010· 10 citedOpen Access
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Frequent Co-authors

Charles F. Albright(22), John E. Macor(20), Lorin A. Thompson(20), Richard E. Olson(15), Jere E. Meredith(14), Kimberley A. Lentz(13), Catherine R. Burton(12), Leland H. Johnston(12), Donna M. Barten(11), Michael K. Ahlijanian(9), James E. Grace(8), Yong‐Jin Wu(8), Lawrence G. Iben(7), Dieter M. Drexler(7), Jason Guernon(7), Jianliang Shi(7), Joanne J. Bronson(6), Lawrence R. Marcin(6), Craig Polson(6), Valerie Guss(6)