Jianliang Shi

Chinese Academy of Sciences — China

Neuroscience · Life Sciences

11h-index215citations19works0.72yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(5), Alzheimer's disease research and treatments(5), Computational Drug Discovery Methods(5), Drug Transport and Resistance Mechanisms(3), Chemical Synthesis and Analysis(3)

Publications19 total

Research on thermal effect induced by focal spot on the wall of the square beam propagation channel and its mitigation
Optics & Laser Technology·2025
Research on thermal effect induced by water vapor and its suppression in closed chamber
Optics Communications·2025
Research on transient thermal effects of dynamic rotating complex enclosed optical system
Optics & Laser Technology·2024· 2 cited
Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization
ACS Medicinal Chemistry Letters·2023· 18 citedOpen Access
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
ACS Medicinal Chemistry Letters·2019· 22 citedOpen Access
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
ACS Medicinal Chemistry Letters·2018· 16 citedOpen Access
CCDC 1827708: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1827709: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1831022: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Development of New Benzenesulfonamides As Potent and Selective Na<sub>v</sub>1.7 Inhibitors for the Treatment of Pain
Journal of Medicinal Chemistry·2017· 36 citedOpen Access
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors
Journal of Medicinal Chemistry·2016· 12 citedOpen Access
Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
ACS Medicinal Chemistry Letters·2016· 30 citedOpen Access
Design and optimization of tricyclic gamma-secretase modulators
Bioorganic & Medicinal Chemistry Letters·2015· 12 citedOpen Access
ChemInform Abstract: Synthesis of β‐Disubstituted β‐Amino Isoxazolyl Ketones by Addition of Ketimines with Isoxazolyl Methyl Ketone Enolates.
ChemInform·2014
Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates
Tetrahedron Letters·2014· 5 cited
Identification and Preclinical Pharmacology of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">γ</mml:mi></mml:mrow></mml:math>-Secretase Modulator BMS-869780
International Journal of Alzheimer s Disease·2014· 13 citedOpen Access
Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 14 citedOpen Access
Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE)
Bioorganic & Medicinal Chemistry Letters·2011· 20 citedOpen Access
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 15 citedOpen Access

Frequent Co-authors

Lorin A. Thompson(15), Richard E. Olson(11), John E. Macor(11), Lawrence R. Marcin(9), Jason Guernon(8), Jeremy H. Toyn(7), Yong‐Jin Wu(6), Charles F. Albright(6), Xiaoliang Zhuo(6), Rex Denton(6), Linda J. Bristow(5), Hyunsoo Park(5), Alicia Ng(5), Mendi A. Higgins(5), Jianqing Li(5), Kimberley A. Lentz(5), Arvind Mathur(5), Joanne J. Bronson(5), Michael K. Ahlijanian(4), Jere E. Meredith(4)