Lawrence R. Marcin

University of New Haven — United States

Chemistry · Physical Sciences

16h-index1.1kcitations51works0.32yr avg
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Research Topics

Asymmetric Synthesis and Catalysis(15), Crystallization and Solubility Studies(9), X-ray Diffraction in Crystallography(9), Synthetic Organic Chemistry Methods(7), Organic Chemistry Cycloaddition Reactions(7)

Publications51 total

1961-LB: Targeted Degradation of Pathogenic Proinsulin and Insulin Autoantibodies with TRAP for the Treatment of Type 1 Diabetes
Diabetes·2025
First-in-Class Antigen-Specific Extracellular Protein Degrader, BHV-1400 for IgA Nephropathy, Selectively Targets Galactose-Deficient IgA for Rapid and Efficient Endolysosomal Degradation in the Liver
Journal of the American Society of Nephrology·2024
BHV-2100, a First-in-class TRPM3 Antagonist for the Treatment of Pain (S13.002)
Neurology·2024· 1 cited
Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481
ACS Medicinal Chemistry Letters·2019· 22 citedOpen Access
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
ACS Medicinal Chemistry Letters·2018· 16 citedOpen Access
CCDC 1827708: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1827709: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1831022: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-D-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder
Journal of Pharmacology and Experimental Therapeutics·2017· 17 citedOpen Access
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia
Bioorganic & Medicinal Chemistry·2016· 12 citedOpen Access
Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors
Journal of Medicinal Chemistry·2016· 12 citedOpen Access
CCDC 1508842: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
CCDC 1508841: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
ChemInform Abstract: Synthesis of β‐Disubstituted β‐Amino Isoxazolyl Ketones by Addition of Ketimines with Isoxazolyl Methyl Ketone Enolates.
ChemInform·2014
Synthesis of β-disubstituted β-amino isoxazolyl ketones by addition of ketimines with isoxazolyl methyl ketone enolates
Tetrahedron Letters·2014· 5 cited
Identification and Preclinical Pharmacology of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi mathvariant="bold-italic">γ</mml:mi></mml:mrow></mml:math>-Secretase Modulator BMS-869780
International Journal of Alzheimer s Disease·2014· 13 citedOpen Access
Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1
Bioorganic & Medicinal Chemistry Letters·2010· 37 cited
ChemInform Abstract: Synthesis and hSERT Activity of Homotryptamine Analogues. Part 6. [3 + 2] Dipolar Cycloaddition of 3‐Vinylindoles.
ChemInform·2010Open Access
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
ACS Medicinal Chemistry Letters·2010· 183 cited
CCDC 749351: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
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Frequent Co-authors

John E. Macor(15), Thaddeus F. Molski(13), Lorin A. Thompson(12), Scott E. Denmark(11), Mendi A. Higgins(11), Joanne J. Bronson(10), Richard E. Olson(10), Jianliang Shi(9), Gail K. Mattson(8), Nicholas J. Lodge(8), Linda J. Bristow(8), Derek J. Denhart(7), Rex Denton(7), Bradley C. Pearce(7), Jeremy H. Toyn(6), Charles F. Albright(6), Ronald J. Mattson(6), Dalton King(6), Jianqing Li(6), Xiaoliang Zhuo(6)