Kulandaivelu S. Vetrivel

University of Chicago — United States

Medicine · Health Sciences

21h-index2.5kcitations32works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(28), Cellular transport and secretion(9), Drug Transport and Resistance Mechanisms(8), Lipid Membrane Structure and Behavior(7), Endoplasmic Reticulum Stress and Disease(5)

Publications32 total

APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model
Cell Reports·2019· 28 citedOpen Access
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease
Proceedings of the National Academy of Sciences·2017· 68 cited
Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase
Molecular Neurodegeneration·2014· 192 citedOpen Access
A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production
Cell Reports·2013· 74 citedOpen Access
Regulation of dynamic BACE1 trafficking in neurons
Molecular Neurodegeneration·2013· 10 citedOpen Access
Ca2+ Influx through Store-operated Ca2+ Channels Reduces Alzheimer Disease β-Amyloid Peptide Secretion
Journal of Biological Chemistry·2013· 40 citedOpen Access
Novel Gα<sub>S</sub>-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain
Journal of Neuroscience·2012· 44 citedOpen Access
Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease
Molecular Neurodegeneration·2012· 2 citedOpen Access
APPプロセシングとAβ産生過程 : AD治療標的としてのセクレターゼの可能性 (特集 アルツハイマー病の根本治療に向けた研究最前線)
細胞工学·2012
Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice
Molecular Neurodegeneration·2011· 21 citedOpen Access
P3‐206: APP intracellular domain enhances neurite outgrowth through gαs coupling to adenylate cyclase signaling
Alzheimer s & Dementia·2011Open Access
Loss of Cleavage at β′-Site Contributes to Apparent Increase in β-Amyloid Peptide (Aβ) Secretion by β-Secretase (BACE1)-Glycosylphosphatidylinositol (GPI) Processing of Amyloid Precursor Protein
Journal of Biological Chemistry·2011· 33 citedOpen Access
Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates
Journal of Biological Chemistry·2010· 27 citedOpen Access
Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann‐Pick type C1‐deficient mouse brains
Glia·2010· 54 cited
Membrane rafts in Alzheimer's disease beta-amyloid production
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2010· 279 citedOpen Access
Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts
Journal of Biological Chemistry·2008· 152 citedOpen Access
S-Palmitoylation of γ-Secretase Subunits Nicastrin and APH-1
Journal of Biological Chemistry·2008· 68 citedOpen Access
Localization and regional distribution of p23/TMP21 in the brain
Neurobiology of Disease·2008· 30 citedOpen Access
P3‐337: S‐palmitoylation targets BACE‐1 to lipid rafts
Alzheimer s & Dementia·2008
O2‐03–01: Exploring β‐secretase activity in lipid raft microdomains
Alzheimer s & Dementia·2008
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Frequent Co-authors

Gopal Thinakaran(31), Angèle Parent(13), Xavier Meckler(10), Haipeng Cheng(9), Philip C. Wong(7), Ping Gong(7), Robert Vassar(6), Satyabrata Kar(6), Tong Li(5), Virginie Buggia-Prévot(5), Jelita Roseman(5), Phuong D. Nguyen(5), Maria Z. Kounnas(5), Steven L. Wagner(5), Vytautas P. Bindokas(4), Huaxi Xu(3), Ying Chen(3), Celia Fernandez(3), Nabil G. Seidah(3), Meghan Carter(3)