Bernard Hulin

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index826citations37works0.02yr avg
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Research Topics

Metabolism, Diabetes, and Cancer(5), Synthesis and biological activity(4), Chemical Synthesis and Analysis(4), Chemical Synthesis and Reactions(4), Crystallization and Solubility Studies(4)

Publications37 total

(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor
Bioorganic & Medicinal Chemistry Letters·2009· 43 citedOpen Access
CCDC 724858: Experimental Crystal Structure Determination
The Cambridge Structural Database·2009Open Access
ChemInform Abstract: Lithium Borohydride: A Reagent of Choice for the Selective Reductive Amination of Cyclohexanones.
ChemInform·2008
Lithium borohydride: a reagent of choice for the selective reductive amination of cyclohexanones
Tetrahedron Letters·2007· 19 cited
New Fluorinated Pyrrolidine and Azetidine Amides as Dipeptidyl Peptidase IV Inhibitors.
ChemInform·2006
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Letters·2005· 36 citedOpen Access
Three‐Component, Stereoselective Palladium‐Catalyzed Synthesis of Functionalized Bicyclopentanoids.
ChemInform·2005Open Access
CCDC 257408: Experimental Crystal Structure Determination
The Cambridge Structural Database·2005Open Access
CCDC 257407: Experimental Crystal Structure Determination
The Cambridge Structural Database·2005Open Access
CCDC 257409: Experimental Crystal Structure Determination
The Cambridge Structural Database·2005Open Access
Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase
Journal of Lipid Research·2004· 21 citedOpen Access
Three-Component, Stereoselective Palladium-Catalyzed Synthesis of Functionalized Bicyclopentanoids
Organic Letters·2004· 13 cited
A practical synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one
Tetrahedron Asymmetry·2004· 14 cited
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
Diabetes·2000· 63 citedOpen Access
ChemInform Abstract: Hypoglycemic Activity of a Series of α‐Alkylthio and α‐ Alkoxy Carboxylic Acids Related to Ciglitazone (XII).
ChemInform·1997· 4 cited
The Glitazone Family of Antidiabetic Agents
Current Pharmaceutical Design·1996· 94 cited
Hypoglycemic Activity of a Series of α-Alkylthio and α-Alkoxy Carboxylic Acids Related to Ciglitazone
Journal of Medicinal Chemistry·1996· 58 cited
1 New Hypoglycaemic Agents
Progress in medicinal chemistry·1994· 23 cited
Synthesis of a biotin conjugate of darglitazone, a new antidiabetic agent. A general protocol for the reversible biotinylation of ketones
Bioorganic & Medicinal Chemistry Letters·1993· 4 cited
ChemInform Abstract: Novel Thiazolidine‐2,4‐diones as Potent Euglycemic Agents.
ChemInform·1993
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Frequent Co-authors

Shawn Cabral(9), E. Michael Gibbs(7), Linda S. Newton(7), Masato Koreeda(6), Stuart L. Schreiber(5), Kim Andrews(5), David A. Clark(4), Steven W. Goldstein(4), Judith L. Treadway(4), Craig A. Townsend(4), W. H. Kappeler(3), C. H. LAMPHERE(3), Ralph W. Stevenson(3), R. Kirk McPherson(3), Janice C. Parker(3), Michael G. Lopaze(3), Jon Bordner(3), Andrew J. Walker(3), Tarek Sammakia(2), Gayle K. Schulte(2)