Shawn Cabral

Pfizer (United States) — United States

Materials Science · Physical Sciences

16h-index796citations36works0.02yr avg
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Research Topics

Crystallization and Solubility Studies(6), X-ray Diffraction in Crystallography(6), Pancreatic function and diabetes(5), Peroxisome Proliferator-Activated Receptors(5), Asymmetric Hydrogenation and Catalysis(5)

Publications36 total

Route Optimization of the Non-covalent Modulator of Hemoglobin PF-07059013 for the Treatment of Sickle Cell Disease, Part I: From Discovery Synthesis to First Kilogram-Scale Manufacture
Organic Process Research & Development·2023· 2 cited
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease
Journal of Medicinal Chemistry·2020· 40 citedOpen Access
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal Chemistry·2020· 29 cited
Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing
Journal of the American Chemical Society·2020· 78 citedOpen Access
Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577
Organic Process Research & Development·2018· 13 cited
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Journal of Medicinal Chemistry·2018· 17 citedOpen Access
Route Selection and Optimization in the Synthesis of Two Imidazopyridine Inhibitors of DGAT-2
Organic Process Research & Development·2018· 7 cited
CCDC 1853363: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile
MedChemComm·2016· 10 citedOpen Access
Development of an O-Vinylation–Ring-Closing Metathesis Strategy to Access 3,3′-3,4-Dihydropyrans
Synlett·2016· 4 cited
The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems
The Journal of Organic Chemistry·2016· 21 cited
Development of a selective activity-based probe for glycosylated LIPA
Bioorganic & Medicinal Chemistry Letters·2016· 3 cited
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Journal of Medicinal Chemistry·2016· 39 citedOpen Access
CCDC 1478860: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
溶質輸送体13(SLC13)ファミリーによるクエン酸輸送のin vivo阻害のためのジカルボキシルシリーズの最適化
Journal of Medicinal Chemistry·2016
CCDC 1455314: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Scientific Reports·2015· 68 citedOpen Access
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase
Bioorganic & Medicinal Chemistry Letters·2015· 18 citedOpen Access
Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)
Journal of Medicinal Chemistry·2015· 80 cited
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Frequent Co-authors

Daniel W. Kung(13), Aaron Smith(9), Gary E. Aspnes(9), Michael Herr(9), Jana Polívková(9), Bernard Hulin(9), Matthew Dowling(8), Mark Niosi(8), Dilinie P. Fernando(8), Kentaro Futatsugi(7), Kim Huard(7), Colin R. Rose(7), Sophie Y. Lavergne(6), Qifang Li(6), J Gosset(6), Nathan E. Genung(6), Benjamin A. Thuma(6), Janice A. Brown(5), Philip A. Carpino(5), Edward L. Conn(5)