Jana Polívková

Pfizer (United States) — United States

Materials Science · Physical Sciences

16h-index724citations60works14.32yr avg
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Research Topics

Crystallization and Solubility Studies(8), X-ray Diffraction in Crystallography(8), Neuropeptides and Animal Physiology(6), Diabetes Treatment and Management(4), Catalytic Cross-Coupling Reactions(4)

Publications60 total

Discovery of small molecule modulators of the thin filament that alter the contractile profile in a hypertrophic cardiomyopathy engineered tissue model
Journal of Biological Chemistry·2025Open Access
Discovery of SARS-CoV-2 papain-like protease (PL <sup>pro</sup> ) inhibitors with efficacy in a murine infection model
Science Advances·2024· 38 citedOpen Access
Discovery of SARS-CoV-2 papain-like protease (PL <sup>pro</sup> ) inhibitors with efficacy in a murine infection model
2024· 5 citedOpen Access
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups
Bioorganic & Medicinal Chemistry Letters·2023· 2 citedOpen Access
CCDC 2237356: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss
Journal of Medicinal Chemistry·2023· 23 citedOpen Access
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal Chemistry·2020· 29 cited
Evolution of the Synthesis of AMPK Activators for the Treatment of Diabetic Nephropathy: From Three Preclinical Candidates to the Investigational New Drug PF-06409577
Organic Process Research & Development·2018· 13 cited
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5′-Adenosine Monophosphate-Activated Protein Kinase (AMPK)
Journal of Medicinal Chemistry·2018· 17 citedOpen Access
CCDC 1853363: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
ChemInform Abstract: Palladium‐Catalyzed β‐(Hetero)arylation of α,β‐Unsaturated Valerolactams.
ChemInform·2016
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Journal of Medicinal Chemistry·2016· 39 citedOpen Access
溶質輸送体13(SLC13)ファミリーによるクエン酸輸送のin vivo阻害のためのジカルボキシルシリーズの最適化
Journal of Medicinal Chemistry·2016
CCDC 1455314: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Palladium-catalyzed β-(hetero)arylation of α,β-unsaturated valerolactams
Organic & Biomolecular Chemistry·2016· 12 cited
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3
Journal of Medicinal Chemistry·2015· 15 citedOpen Access
ChemInform Abstract: Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides.
ChemInform·2014· 1 cited
Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides
Organic Letters·2013· 152 cited
Spirolactam-Based Acetyl-CoA Carboxylase Inhibitors: Toward Improved Metabolic Stability of a Chromanone Lead Structure
Journal of Medicinal Chemistry·2013· 47 citedOpen Access
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Frequent Co-authors

Shawn Cabral(8), Dilinie P. Fernando(8), Daniel W. Kung(8), Michael Herr(7), J. Pospı́šil(7), Sophie Y. Lavergne(6), Kim Huard(6), David J. Edmonds(6), Aaron Smith(6), David W. Piotrowski(6), Qifang Li(6), Colin R. Rose(6), Yingxin Zhang(6), Kevin B. Bahnck(5), Gary E. Aspnes(5), Amit S. Kalgutkar(5), Matthew Dowling(5), Kimberly O. Cameron(5), P Poučková(5), Shawn D. Doran(4)