Kim Huard

Chemistry · Physical Sciences

16h-index1.3kcitations34works0.02yr avg
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Research Topics

Catalytic C–H Functionalization Methods(8), Synthesis and Catalytic Reactions(8), Cyclopropane Reaction Mechanisms(6), Pancreatic function and diabetes(5), Drug Transport and Resistance Mechanisms(4)

Publications34 total

The Effect of <i>N</i> -Alkyl Azole Difluorination on Molecular Properties Relevant for Compound Optimization: A Comparative Study
ACS Medicinal Chemistry Letters·2026Open Access
Targeting PTPN22 at Nonorthosteric Binding Sites─A Fragment Approach
ACS Omega·2026Open Access
CCDC 2279783: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023· 1 citedOpen Access
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
It's ok to be outnumbered – sub-stoichiometric modulation of homomeric protein complexes
RSC Medicinal Chemistry·2022· 2 citedOpen Access
CCDC 2098502: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Journal of Medicinal Chemistry·2020· 69 citedOpen Access
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting
Journal of Medicinal Chemistry·2020· 29 cited
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models
Emerging Microbes & Infections·2019· 43 citedOpen Access
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
6員複素環のマルチエンドポイント適合分子対(MMP)分析
Bioorganic & Medicinal Chemistry·2017
Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile
MedChemComm·2016· 10 citedOpen Access
A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles
Bioorganic & Medicinal Chemistry·2016· 13 cited
Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors
Molecular Pharmacology·2016· 26 citedOpen Access
Determination of Unbound Partition Coefficient and in Vitro–in Vivo Extrapolation for SLC13A Transporter–Mediated Uptake
Drug Metabolism and Disposition·2016· 30 cited
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family
Journal of Medicinal Chemistry·2016· 39 citedOpen Access
溶質輸送体13(SLC13)ファミリーによるクエン酸輸送のin vivo阻害のためのジカルボキシルシリーズの最適化
Journal of Medicinal Chemistry·2016
CCDC 1455314: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5)
Scientific Reports·2015· 68 citedOpen Access
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3
Journal of Medicinal Chemistry·2015· 15 citedOpen Access
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Frequent Co-authors

H. Lebel(10), Kentaro Futatsugi(9), Thomas V. Magee(7), Shawn Cabral(7), Mark Niosi(7), J Gosset(7), Jana Polívková(7), Aaron Smith(6), Matthew Dowling(6), Jeffrey A. Pfefferkorn(6), Sylvain Lectard(5), Steven B. Coffey(5), Gregory J. Tesz(5), Matthew Gorgoglione(5), Gary E. Aspnes(5), Michael Herr(5), Derek M. Erion(5), Kay Ahn(4), Dilinie P. Fernando(4), Jemy A. Gutierrez(4)