Gregory J. Tesz

Pfizer (United States) — United States

Medicine · Health Sciences

17h-index2.3kcitations33works4.72yr avg
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Research Topics

Pancreatic function and diabetes(11), Diet, Metabolism, and Disease(10), Liver Disease Diagnosis and Treatment(7), Peroxisome Proliferator-Activated Receptors(6), Metabolism, Diabetes, and Cancer(5)

Publications33 total

Impaired hepatic metabolism in Hereditary Fructose Intolerance confers fructose-independent risk for steatosis and hypertriglyceridemia
Molecular Metabolism·2025Open Access
Whole body MondoA deletion protects against diet-induced obesity through uncontrolled multi-organ substrate utilization and futile cycling
2025Open Access
Targeting <scp>PNPLA3</scp> to Treat <scp>MASH</scp> and <scp>MASH</scp> Related Fibrosis and Cirrhosis
Liver International·2024· 14 citedOpen Access
RECENT ADVANCES IN SMALL-MOLECULE INHIBITORS OF KETOHEXOKINASE (KHK)
Medicinal chemistry reviews·2023· 1 cited
Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life
ACS Medicinal Chemistry Letters·2023· 3 citedOpen Access
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr-/-.Leiden mice
Journal of Hepatology·2023
Translational characterization of the temporal dynamics of metabolic dysfunctions in liver, adipose tissue and the gut during diet-induced NASH development in Ldlr−/−.Leiden mice
Heliyon·2023· 10 citedOpen Access
Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis
Journal of Medicinal Chemistry·2022· 25 cited
Serine catabolism generates liver NADPH and supports hepatic lipogenesis
Nature Metabolism·2021· 105 citedOpen Access
CCDC 2098502: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Serine catabolism generates NADPH to support hepatic lipogenesis
2021Open Access
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction
Molecular Metabolism·2021· 80 citedOpen Access
Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose
Journal of Medicinal Chemistry·2020· 69 citedOpen Access
Finding the Sweet Spot: Parsing Tissue-Specific Contributions of Fructose Metabolism
Cell Metabolism·2020· 7 citedOpen Access
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition
Science Translational Medicine·2019· 62 cited
The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids
Cell Metabolism·2018· 621 citedOpen Access
Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)
Journal of Medicinal Chemistry·2017· 49 citedOpen Access
Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3
Journal of Medicinal Chemistry·2015· 15 citedOpen Access
RNAi-based therapeutic strategies for metabolic disease
Nature Reviews Endocrinology·2011· 107 cited
Glucan particles for selective delivery of siRNA to phagocytic cells in mice
Biochemical Journal·2011· 114 cited
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Frequent Co-authors

Michael Czech(7), Gang Xing(7), Walter S. Zawalich(7), Kathleen C. Zawalich(7), Jeffrey A. Pfefferkorn(6), Jemy A. Gutierrez(5), Sylvie Perez(5), Thomas V. Magee(5), Kendra K. Bence(5), Kentaro Futatsugi(5), Steven B. Coffey(5), Kim Huard(5), Myriam Aouadi(4), Michelle Clasquin(4), Trenton T. Ross(4), Kay Ahn(4), Matthew Dowling(4), Ingrid A. Stock(4), Joshua D. Rabinowitz(3), Sarah M. Nicoloro(3)