Benjamin C. Jennings

Washington University in St. Louis — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index915citations35works0.72yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(8), Cellular transport and secretion(8), SARS-CoV-2 and COVID-19 Research(6), Glycosylation and Glycoproteins Research(4), Receptor Mechanisms and Signaling(4)

Publications35 total

An unconventional HxD motif orchestrates coatomer-dependent coronavirus morphogenesis
2025Open Access
Secretory biogenesis and design of a next-generation coronavirus genetic vaccine
Structural Dynamics·2025Open Access
LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase
Molecular Biology of the Cell·2025· 1 cited
Molecular Insights into the Regulation of GNPTAB by TMEM251
2024· 1 citedOpen Access
Structure of a truncated human GlcNAc-1-phosphotransferase variant reveals the basis for its hyperactivity
Journal of Biological Chemistry·2024· 2 citedOpen Access
Structural restraints in the SARS-CoV-2 spike tail control its intra-cellular trafficking to virion assembly and immune presentation sites
Biophysical Journal·2024
A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs
Nature Communications·2023· 16 citedOpen Access
Structural insights into <i>N</i>-linked glycan remodeling of the SARS-Cov-2 spike protein
Acta Crystallographica Section A Foundations and Advances·2023
Atomic-level determinants of SARS-Cov-2 spike trafficking during infection and vaccination
Acta Crystallographica Section A Foundations and Advances·2023Open Access
A single C-terminal residue controls SARS-CoV-2 spike trafficking and virion assembly
2023· 3 citedOpen Access
Structure of the human GlcNAc-1-phosphotransferase αβ subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation
Nature Structural & Molecular Biology·2022· 19 citedOpen Access
A weak COPI binding motif in the cytoplasmic tail of SARS‐CoV‐2 spike glycoprotein is necessary for its cleavage, glycosylation, and localization
FEBS Letters·2021· 32 citedOpen Access
Inactivation of the three <i>GGA</i> genes in HeLa cells partially compromises lysosomal enzyme sorting
FEBS Open Bio·2020· 6 citedOpen Access
Disease‐causing missense mutations within the N‐terminal transmembrane domain of GlcNAc‐1‐phosphotransferase impair endoplasmic reticulum translocation or Golgi retention
Human Mutation·2020· 3 citedOpen Access
Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer
Nature Genetics·2019· 53 citedOpen Access
SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent
Biochemistry·2018· 13 citedOpen Access
In Search of the lost city of Therouanne,a new integrated approach
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)·2017
The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.
Journal of Biological Chemistry·2016· 9 citedOpen Access
The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases
Journal of Biological Chemistry·2016· 31 citedOpen Access
Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase
Bioorganic & Medicinal Chemistry Letters·2015· 14 citedOpen Access
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Frequent Co-authors

Balraj Doray(14), Maurine E. Linder(13), Stuart Kornfeld(7), Suruchi Singh(7), S. Saif Hasan(7), Debajit Dey(6), Carol A. Fierke(5), Enya Qing(5), Brian G. Pierce(5), Tom Gallagher(5), Wang‐Sik Lee(4), Whitaker Cohn(4), Lokesh Gakhar(4), Nicholas Schnicker(4), Julian P. Whitelegge(4), John Orban(4), Patrick Gonyo(3), Ellen Lorimer(3), Jeremy W. Prokop(3), Carol L. Williams(3)