Barbora Hrčka Krausová

Czech Academy of Sciences — Czech Republic

Neuroscience · Life Sciences

16h-index1.0kcitations45works4.42yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(32), Receptor Mechanisms and Signaling(12), Ion channel regulation and function(11), Estrogen and related hormone effects(6), Genetics and Neurodevelopmental Disorders(6)

Publications45 total

Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes
Cellular and Molecular Life Sciences·2026Open Access
Author response for "Positive Modulators of N-Methyl-D-Aspartate Receptor: Structure-Activity Relationship Study on Steroidal C-17 and C-20 Oxime Ethers"
2026
Positive modulators of <i>N</i> -methyl- <scp>d</scp> -aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers
RSC Advances·2026Open Access
Positive Modulators of <i>N</i> -Methyl- <i>D</i> -Aspartate Receptor: Structure-Activity Relationship Study on Steroidal C-17 and C-20 Oxime Ethers
2025Open Access
Phenotype of mice carrying an NMDA receptor GluN2B protein-truncating variant associated with intellectual disability
2025Open Access
Disruption of <i>grin2A</i> , an Epilepsy-Associated Gene, Produces Altered Spontaneous Swim Behavior in Zebrafish
Journal of Neuroscience·2025· 1 citedOpen Access
Disruption of <i>grin2A</i> , an epilepsy-associated gene, produces altered spontaneous swim behavior in zebrafish
2025Open Access
Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology
Physiological Research·2024· 25 citedOpen Access
Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant
Journal of Neuroscience·2024· 12 citedOpen Access
5β-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia
The Journal of Steroid Biochemistry and Molecular Biology·2024· 1 cited
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids
Cellular and Molecular Life Sciences·2024· 3 citedOpen Access
Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition
European Journal of Medicinal Chemistry·2024· 11 citedOpen Access
Subunit-Dependent Surface Mobility and Localization of NMDA Receptors in Hippocampal Neurons Measured Using Nanobody Probes
Journal of Neuroscience·2023· 6 citedOpen Access
Effects of Pregnanolone Glutamate and Its Metabolites on GABA<sub>A</sub> and NMDA Receptors and Zebrafish Behavior
ACS Chemical Neuroscience·2023· 10 citedOpen Access
Phenoxytacrine Derivatives: Low-Toxicity Neuroprotectants Exerting Affinity to Ifenprodil-Binding Site and Cholinesterase Inhibition
SSRN Electronic Journal·2023· 1 citedOpen Access
The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors
Neuropharmacology·2022· 16 citedOpen Access
Pregnane‐based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss‐of‐function disease‐associated <i>GRIN</i> mutations
British Journal of Pharmacology·2022· 13 citedOpen Access
Pharmacokinetic, pharmacodynamic, and behavioural studies of deschloroketamine in Wistar rats
British Journal of Pharmacology·2021· 11 citedOpen Access
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia
Biomolecules·2021· 6 citedOpen Access
Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms
British Journal of Pharmacology·2021· 11 citedOpen Access
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Frequent Co-authors

Ladislav Vyklický(29), Tereza Smejkalová(20), Vojtěch Vyklický(18), Miloslav Kořı́nek(16), Hana Chodounská(16), Eva Kudová(16), Martin Hořák(15), Jiří Černý(14), Aleš Balík(13), Bohdan Kysilov(13), Martina Kaniaková(9), Marek Ladislav(9), Klevinda Fili(8), Karel Valeš(7), Marharyta Kolcheva(7), Mark Dobrovolski(7), Vera Abramova(7), Paulína Božíková(7), Michaela Nekardová(6), Barbora Slavı́ková(6)