Naruhisa Ota

Gene Therapy Laboratory — France

Immunology and Microbiology · Life Sciences

23h-index2.7kcitations30works6.02yr avg
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Research Topics

Immune Cell Function and Interaction(9), Psoriasis: Treatment and Pathogenesis(8), IL-33, ST2, and ILC Pathways(7), Cytokine Signaling Pathways and Interactions(5), Whipple's Disease and Interleukins(5)

Publications30 total

Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling
Proceedings of the National Academy of Sciences·2025· 6 citedOpen Access
IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
Microbiome·2023· 56 citedOpen Access
Additional file 2 of IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans
Figshare·2023Open Access
Structure of the core human NADPH oxidase NOX2
Nature Communications·2022· 92 citedOpen Access
IL-1R1–dependent signaling coordinates epithelial regeneration in response to intestinal damage
Science Immunology·2021· 51 cited
Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes
The Journal of Immunology·2019· 34 cited
LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation
The Journal of Immunology·2018· 43 citedOpen Access
Inflammatory Bowel Disease Susceptibility Gene <i>C1ORF106</i> Regulates Intestinal Epithelial Permeability
ImmunoHorizons·2018· 16 citedOpen Access
Mice deficient in NRROS show abnormal microglial development and neurological disorders
Nature Immunology·2017· 70 cited
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling·2017· 58 cited
The IL-20 Subfamily of Cytokines and Their Receptors
Elsevier eBooks·2016
Interleukin-22 Induces Interleukin-18 Expression from Epithelial Cells during Intestinal Infection
Immunity·2015· 183 citedOpen Access
Dendritic cell CD83 homotypic interactions regulate inflammation and promote mucosal homeostasis
Mucosal Immunology·2014· 49 citedOpen Access
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
Nature·2014· 477 cited
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity
Nature·2014· 242 cited
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers
Mucosal Immunology·2013· 171 citedOpen Access
Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice
Mucosal Immunology·2011· 107 cited
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells
Nature Immunology·2011· 192 cited
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
Nature Immunology·2011· 156 cited
No Requirement of <i>Trans</i> Presentations of IL-15 for Human CD8 T Cell Proliferation
The Journal of Immunology·2010· 28 citedOpen Access
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Frequent Co-authors

Wenjun Ouyang(12), Kit Hong Wong(6), Céline Eidenschenk(5), Lauri Diehl(5), Patrick Caplazi(5), Jason A. Hackney(5), Tangsheng Yi(5), Paolo Manzanillo(4), Sascha Rutz(4), Rajita Pappu(4), Vladimir Ramirez-Carrozzi(4), Merone Roose‐Girma(4), Søren Warming(4), Xiaoting Wang(3), Wyne P. Lee(3), Rajkumar Noubade(3), Ivan Peng(3), Yan Zheng(3), Osami Kanagawa(3), Mary Keir(3)