Kathleen H. Holt

University of Iowa — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index2.5kcitations25works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(10), Metabolism, Diabetes, and Cancer(5), Muscle Physiology and Disorders(4), CRISPR and Genetic Engineering(4), Viral Infectious Diseases and Gene Expression in Insects(4)

Publications25 total

Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors
Molecular Therapy — Methods & Clinical Development·2020· 134 citedOpen Access
Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis
Frontiers in Oncology·2020· 57 citedOpen Access
Methods Matter -- Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors
2019· 10 citedOpen Access
Lentiviral Vectors Pseudotyped with Filoviral Glycoproteins
Methods in molecular biology·2017· 20 citedOpen Access
A mouse knockout library for secreted and transmembrane proteins
Nature Biotechnology·2010· 333 cited
High‐throughput Screening of Mouse Knockout Lines Identifies True Lean and Obese Phenotypes
Obesity·2008· 61 cited
GENERATION OF TRANSGENIC ANIMALS
Elsevier eBooks·2007· 8 cited
CONTRIBUTORS
Elsevier eBooks·2007
High-Throughput Mouse Knockouts Provide a Functional Analysis of the Genome
Cold Spring Harbor Symposia on Quantitative Biology·2003· 16 cited
Full-speed mammalian genetics: in vivo target validation in the drug discovery process
Trends in biotechnology·2002· 46 cited
Biosynthesis of dystroglycan: processing of a precursor propeptide
FEBS Letters·2000· 179 citedOpen Access
Membrane Targeting and Stabilization of Sarcospan Is Mediated by the Sarcoglycan Subcomplex
The Journal of Cell Biology·1999· 149 citedOpen Access
Assembly of the Sarcoglycan Complex
Journal of Biological Chemistry·1998· 128 citedOpen Access
Progressive Muscular Dystrophy in α-Sarcoglycan–deficient Mice
The Journal of Cell Biology·1998· 353 citedOpen Access
Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using δ-Sarcoglycan Gene Transfer
Molecular Cell·1998· 127 citedOpen Access
Chapter 6 Molecular basis of insulin action
Advances in molecular and cellular endocrinology·1997
Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation
Journal of Biological Chemistry·1996· 66 citedOpen Access
Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex
Journal of Biological Chemistry·1996· 42 citedOpen Access
Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid system.
Endocrinology·1996· 52 cited
SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways
Journal of Biological Chemistry·1996· 182 citedOpen Access
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Frequent Co-authors

Jeffrey E. Pessin(10), Brian Zambrowicz(6), Kevin P. Campbell(5), David Venzke(4), Kenneth A. Platt(4), Derek E. Eberhart(4), Steven B. Waters(4), Volker Straub(3), Rachelle H. Crosbie(3), Gwenn M. Hansen(3), Alejandro Abuin(3), Patrick L. Sinn(3), Laura Kirkpatrick(3), Arthur Sands(3), Franck Duclos(2), Connie S. Lebakken(2), Leland E. Lim(2), Joshua R. Sanes(2), Beverly L. Davidson(2), Alan R. Saltiel(2)