Ann M. Leen

Texas Children's Hospital — United States

Medicine · Health Sciences

55h-index10.3kcitations353works8.12yr avg
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Research Topics

CAR-T cell therapy research(196), Virus-based gene therapy research(118), Cytomegalovirus and herpesvirus research(113), Immune Cell Function and Interaction(83), Immunotherapy and Immune Responses(80)

Publications352 total

Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial
Nature Medicine·2026Open Access
Targeting Mesothelin via the native T cell receptor
2025
Autologous multiantigen-targeted T cell therapy for pancreatic ductal adenocarcinoma (PDAC): results of a Phase I, three-arm, nonrandomized clinical trial (TACTOPS)
immuneACCESS·2025
IL-7 armed binary CAR T cell strategy to augment potency against solid tumors
Frontiers in Immunology·2025· 7 citedOpen Access
IL-7 armed binary CAR T cell strategy to augment potency against solid tumors
2025Open Access
Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
Science Advances·2025· 12 citedOpen Access
Virus-Specific T-Cell Therapy for the Management of Viral Infections in the Immunocompromised
Transfusion Medicine and Hemotherapy·2024· 4 citedOpen Access
Final outcomes from a phase 2 trial of posoleucel in allogeneic hematopoietic cell transplant recipients
Blood Advances·2024· 16 citedOpen Access
LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001): results from arm 1 of a non-randomised, single-centre, phase 1/2 study
The Lancet Oncology·2024· 54 citedOpen Access
Phenotypic and functional characterization of posoleucel, a multivirus-specific T cell therapy for the treatment and prevention of viral infections in immunocompromised patients
Cytotherapy·2024· 4 cited
Assessment of the Cytolytic Potential of a Multivirus-Targeted T Cell Therapy Using a Vital Dye-Based, Flow Cytometric Assay
Transplantation and Cellular Therapy·2024
Phenotypic and Functional Characterization of Posoleucel, a Multivirus-Specific T Cell Therapy for the Treatment and Prevention of Viral Infections in Immunocompromised Patients
Transplantation and Cellular Therapy·2024· 1 cited
Incongruity between T cell receptor recognition of breast cancer hotspot mutations ESR1 Y537S and D538G following exogenous peptide loading versus endogenous antigen processing
Cytotherapy·2024· 2 citedOpen Access
Targeting IDH2R140Q and other neoantigens in acute myeloid leukemia
Blood·2024· 15 citedOpen Access
A dual-luciferase bioluminescence system for the assessment of cellular therapies
Molecular Therapy Oncology·2024· 6 citedOpen Access
Assessment of the cytolytic potential of a multivirus-targeted T cell therapy using a vital dye-based, flow cytometric assay
Frontiers in Immunology·2023· 7 citedOpen Access
Immune Profiling of Respiratory Syncytial Virus (RSV) for the Development of Targeted Immunotherapy
Blood·2023
T cell immune profiling of respiratory syncytial virus for the development of a targeted immunotherapy
British Journal of Haematology·2023· 7 citedOpen Access
Immunotherapy: DISCOVERY OF BREAST CANCER SPECIFIC TCRS COVERING A BROAD RANGE OF COMMON HLA ALLELES
Cytotherapy·2023
Therapy With Allogeneic Severe Acute Respiratory Syndrome Coronavirus-2–Specific T Cells for Persistent Coronavirus Disease 2019 in Immunocompromised Patients
Clinical Infectious Diseases·2023· 15 citedOpen Access
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Frequent Co-authors

Cliona M. Rooney(38), Helen E. Heslop(33), Malcolm K. Brenner(29), Catherine M. Bollard(18), Adrian P. Gee(12), Ulrike Gerdemann(12), Juan F. Vera(12), Stephen Gottschalk(10), Barbara Savoldo(10), Gianpietro Dotti(9), Robert A. Krance(8), Hao Liu(7), Pradip Bajgain(7), Kathryn Leung(6), Caridad Martinez(6), Carolina Colli Cruz(6), Patrick J. Hanley(6), Norihiro Watanabe(6), Elizabeth J. Shpall(5), Carlos A. Ramos(5)