Thijn R. Brummelkamp

Dutch Cancer Society — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

69h-index28.6kcitations189works11.82yr avg
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Research Topics

Ubiquitin and proteasome pathways(32), Estrogen and related hormone effects(23), CRISPR and Genetic Engineering(20), Genomics and Chromatin Dynamics(19), DNA Repair Mechanisms(17)

Publications189 total

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Nature Communications·2025Open Access
SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
2025· 1 citedOpen Access
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target
Nature·2025· 4 cited
NASP modulates histone turnover to drive PARP inhibitor resistance
Nature·2025· 4 citedOpen Access
Zincore, an atypical coregulator, binds zinc finger transcription factors to control gene expression
Science·2025· 3 citedOpen Access
Condensin II activation by M18BP1
Molecular Cell·2025· 9 citedOpen Access
PLA2G15 is a BMP hydrolase and its targeting ameliorates lysosomal disease
Nature·2025· 16 citedOpen Access
SRBD1, a highly conserved gene required for chromosome individualization
Cell Reports·2025· 5 citedOpen Access
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
2025· 1 citedOpen Access
Identification of critical factors of the replication stress response in human cells
2025· 1 citedOpen Access
Chromatin protein complexes involved in gene repression in lamina-associated domains
The EMBO Journal·2024· 7 citedOpen Access
PLA2G15 is a Lysosomal BMP Hydrolase and its Targeting Ameliorates Lysosomal Disease
2024· 6 citedOpen Access
Decoding microtubule detyrosination: enzyme families, structures, and functional implications
FEBS Letters·2024· 6 citedOpen Access
DNA damage induces p53-independent apoptosis through ribosome stalling
Science·2024· 94 citedOpen Access
Chromatin protein complexes involved in gene repression in lamina-associated domains
2024· 1 citedOpen Access
Condensin II activation by M18BP1
2024· 8 citedOpen Access
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
Nature Structural & Molecular Biology·2024· 34 citedOpen Access
Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
2023· 8 citedOpen Access
CMTM6 shapes antitumor T cell response through modulating protein expression of CD58 and PD-L1
Cancer Cell·2023· 40 citedOpen Access
Identification of an alternative triglyceride biosynthesis pathway
Nature·2023· 71 citedOpen Access
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Frequent Co-authors

Vincent A. Blomen(14), Jan E. Carette(12), René Bernards(11), Lucas T. Jae(10), Matthijs Raaben(9), John M. Dye(8), Ana I. Kuehne(7), Sebastian Nijman(6), Andrew S. Herbert(6), Sean P. J. Whelan(6), Kartik Chandran(6), Reuven Agami(4), Arno Velds(4), Ron Kerkhoven(4), Joppe Nieuwenhuis(4), Annette M.G. Dirac(3), Fernando D. Camargo(3), George W. Bell(3), Mandy Madiredjo(3), Roderick L. Beijersbergen(3)