René Bernards

Shanghai Jiao Tong University — China

Medicine · Health Sciences

110h-index77.3kcitations878works14.02yr avg
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Research Topics

Cancer-related Molecular Pathways(84), Cancer Genomics and Diagnostics(81), Melanoma and MAPK Pathways(81), Protein Degradation and Inhibitors(74), PI3K/AKT/mTOR signaling in cancer(69)

Publications878 total

European cancer research requires renewed urgency
Nature Cancer·2025
Efficacy and safety of atezolizumab plus bevacizumab in MSI-like metastatic colorectal cancer: a multicenter, single-arm, phase II, open-label clinical trial
ESMO Open·2025Open Access
Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
Nature Protocols·2025· 1 cited
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma
Proceedings of the National Academy of Sciences·2025Open Access
A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma
Molecular Oncology·2025Open Access
Prospects for understanding and exploiting the consequences of hyperactivation lethality
Trends in cancer·2025· 5 citedOpen Access
Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability
Proceedings of the National Academy of Sciences·2025Open Access
Afadin loss induces breast cancer metastasis through destabilisation of E‐cadherin to F‐actin linkage
The Journal of Pathology·2025· 5 citedOpen Access
PEBP1 is a candidate biomarker of response to the PP2A inhibitor LB-100
2025· 1 citedOpen Access
Hepatocellular carcinoma: signaling pathways and therapeutic advances
Signal Transduction and Targeted Therapy·2025· 174 citedOpen Access
DYRK1A-TGF-β signaling axis determines sensitivity to OXPHOS inhibition in hepatocellular carcinoma
Developmental Cell·2025· 6 cited
Apoptotic priming in senescence predicts specific senolysis by quantitative analysis of mitochondrial dependencies
Cell Death and Differentiation·2025· 8 cited
Deciphering the role of the MALT1–RC3H1 axis in regulating GPX4 protein stability
Proceedings of the National Academy of Sciences·2024· 12 citedOpen Access
Mitochondrial damage triggers therapy-induced senescence
2024Open Access
Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state
Cell Death and Differentiation·2024· 11 cited
An antibiotic that mediates immune destruction of senescent cancer cells
Proceedings of the National Academy of Sciences·2024· 8 citedOpen Access
Perturbation of mRNA splicing in liver cancer: insights, opportunities and challenges
Gut·2024· 6 cited
Efficacy and safety of lenvatinib plus gefitinib in lenvatinib-resistant hepatocellular carcinomas: a prospective, single-arm exploratory trial
Signal Transduction and Targeted Therapy·2024· 15 citedOpen Access
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
Cancer Cell·2024· 56 cited
An antibiotic that mediates immune destruction of senescent cancer cells
2024
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Frequent Co-authors

Roderick L. Beijersbergen(12), Thijn R. Brummelkamp(7), Lodewyk F.A. Wessels(6), Liqin Wang(6), Andreas Schlicker(5), Anirudh Prahallad(5), Chong Sun(5), Cor Lieftink(5), Laura van ‘t Veer(4), Marc J. van de Vijver(4), Ron Kerkhoven(4), Stephen Friend(4), Ramón Salazar(4), Reuven Agami(4), Sidong Huang(4), Alberto Bardelli(4), Sebastian Nijman(4), Annette M.G. Dirac(4), Mandy Madiredjo(4), Wipawadee Grernrum(4)