Nyanza J. Rothman

Immunology and Microbiology · Life Sciences

13h-index1.0kcitations29works0.02yr avg
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Research Topics

Immune Cell Function and Interaction(6), T-cell and B-cell Immunology(5), Lysosomal Storage Disorders Research(5), Heterotopic Ossification and Related Conditions(5), Medical Imaging and Pathology Studies(5)

Publications29 total

Preclinical evaluation of a durable, tissue-targeted gene therapy for Pompe disease demonstrates superior efficacy over standard ERT
Molecular Genetics and Metabolism·2026
Skeletal phenotype amelioration in mucopolysaccharidosis VI requires intervention at the earliest stages of postnatal development
JCI Insight·2023· 8 citedOpen Access
Delivering therapeutic lysosomal enzyme to the CNS: A rapid, large-scale screen identifies optimal characteristics of BBB-crossing TFRC antibodies
Molecular Genetics and Metabolism·2023· 2 cited
Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
Journal of Clinical Investigation·2022· 60 citedOpen Access
BBB-targeted GAA delivered as gene therapy treats CNS and muscle in Pompe disease model mice
Molecular Genetics and Metabolism·2022
Defining phenotype reversibility in lysosomal disease: Leveraging a COIN model in mucopolysaccharidosis type VI (MPS VI)
Molecular Genetics and Metabolism·2022
Functional modeling of human lysosomal acid alpha-glucosidase variants
Molecular Genetics and Metabolism·2022
ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1
2021· 1 citedOpen Access
Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes
The Journal of Experimental Medicine·2020· 95 citedOpen Access
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
eLife·2020· 78 citedOpen Access
Author response: Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
2020Open Access
The finger 2 tip loop of Activin A is required for the formation of its non-signaling complex with ACVR1 and type II Bone Morphogenetic Protein receptors
2019· 1 citedOpen Access
Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells
ImmunoHorizons·2018Open Access
Metabolic control of cell fate bifurcations in a hematopoietic progenitor population
Immunology and Cell Biology·2018· 47 cited
Correction: IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination
ImmunoHorizons·2018Open Access
Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway
Cell Reports·2018· 35 citedOpen Access
IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination
ImmunoHorizons·2017· 12 citedOpen Access
Eomesodermin and T-bet mark developmentally distinct human natural killer cells
JCI Insight·2017· 48 citedOpen Access
CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions
The Journal of Experimental Medicine·2016· 111 citedOpen Access
Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal
Cell Reports·2016· 114 citedOpen Access
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Frequent Co-authors

Steven L. Reiner(12), Aris N. Economides(9), Simone A. Nish(8), Bonnie Yen(8), Yen‐Hua Chen(8), Radomir Kratchmarov(8), Wen-Hsuan W. Lin(7), William C. Adams(7), Kalyan C. Nannuru(7), John B. Lees‐Shepard(7), Katherine D. Cygnar(6), Senem Aykul(5), Andrew Murphy(5), Vincent Idone(5), Andrew D. Baik(5), Ulf Klein(4), Nanditha Das(4), Michael Lueckheide(4), Bona Ko(4), Joseph M. Tanski(4)